MED15 and MED25

Number of citations of the paper that reports this interaction (PubMedID 14983011)
39

Data Source:
HPRD (in vivo)

		MED15	MED25
Description		mediator complex subunit 15	mediator complex subunit 25
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Core Mediator Complex	Nucleus Nucleoplasm Transcription Regulator Complex Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding	Transcription Coactivator Binding Protein Binding Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding
	Biological Process	Regulation Of DNA-templated Transcription Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Mediator Complex Assembly
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Lung function (FEV1/FVC) ( 30061609)	Blood trace element (Se levels) ( 23720494)
Interacting Genes		13 interacting genes: ATP5F1C ATXN1 CEBPA CTDP1 FHL3 MED25 MLLT6 PLSCR1 RELA SMAD2 SMAD3 TRIM11 UBC	38 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SENP3 SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2
Entrez ID		51586	81857
HPRD ID		12117	14380
Ensembl ID		ENSG00000099917	ENSG00000104973
Uniprot IDs		B3KWF1 B7Z2H7 G3V1P5 Q6PKB8 Q96RN5	M0QZQ2 Q71SY5
PDB IDs		2GUT 7EMF 7ENA 7ENC 7ENJ 7LBM 8GXQ 8GXS 8J9A 8T9D 8TQW 8TRH	2KY6 2L23 2L6U 2XNF 7EMF 7LBM 8GXQ 8GXS 8T9D
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Mesoderm Morphogenesis Pericardium Development Transcription Coactivator Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific SMAD Protein Complex Trophoblast Cell Migration Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Chromatin Binding Nucleobase-containing Compound Biosynthetic Process Embryonic Foregut Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Nodal Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Nucleoplasm Nucleus Liver Development Osteoblast Development I-SMAD Binding Ubiquitin Protein Ligase Binding Transforming Growth Factor Beta Receptor Binding Negative Regulation Of Cell Differentiation Negative Regulation Of Multicellular Organismal Process Double-stranded DNA Binding Protein-containing Complex Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Signal Transduction Response To Virus Response To Angiotensin R-SMAD Binding Negative Regulation Of MiRNA Transcription	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nuclear Receptor Activity Core Mediator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Mediator Complex Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process Transcription Coregulator Activity Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Intracellular Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleoplasm Hormone-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway COPII Vesicle Coating Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription
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