MED15 and MED25

Number of citations of the paper that reports this interaction (PMID 14983011)
49

Data Source:
HPRD (in vivo)

		MED15	MED25
Gene Name		mediator complex subunit 15	mediator complex subunit 25
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Mediator Complex	Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		12 interactors: ATP5C1 ATXN1 CTDP1 FHL3 MED25 MLLT6 PLSCR1 RELA SMAD2 SMAD3 TRIM11 UBC	16 interactors: CDK8 CREBBP CTDP1 ESR1 HCFC1 MED1 MED15 MED4 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA
Entrez ID		51586	81857
HPRD ID		12117	14380
Ensembl ID		ENSG00000099917	ENSG00000104973
Uniprot IDs		B4DGD6 G3V1P5 Q96RN5	Q71SY5
PDB IDs		2GUT	2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Primary MiRNA Processing RNA Biosynthetic Process DNA-templated Transcription, Initiation SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Paraxial Mesoderm Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Nodal Signaling Pathway Regulation Of Nucleic Acid-templated Transcription RNA Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Expression Regulation Of Viral Process Positive Regulation Of Chondrocyte Differentiation Pericardium Development Defense Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Cellular Response To Lipid Steroid Hormone Mediated Signaling Pathway Regulation Of Metabolic Process Response To Steroid Hormone Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription From RNA Polymerase II Promoter Steroid Metabolic Process Gland Development Response To Lipid Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Response To Hormone Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		9aatad 9aatads alignment ambiguous analogy architecture belong cmyb differently e2a formations foxo3 gcn4 heb helical kix leucine mll oaf1 pdr1 plausible position requirements resolved shares shed structural tad transactivation	allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Difference) ?		9aatad 9aatads alignment ambiguous analogy architecture belong cmyb differently e2a formations foxo3 gcn4 heb helical kix leucine mll oaf1 pdr1 plausible position requirements resolved shares shed structural tad transactivation	allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Intersection) ?