MED15

Description		mediator complex subunit 15
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Core Mediator Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Lung function (FEV1/FVC) ( 30061609)
Interacting Genes		13 interacting genes: ATP5F1C ATXN1 CEBPA CTDP1 FHL3 MED25 MLLT6 PLSCR1 RELA SMAD2 SMAD3 TRIM11 UBC
Entrez ID		51586
HPRD ID		12117
Ensembl ID		ENSG00000099917
Uniprot IDs		B3KWF1 B7Z2H7 G3V1P5 Q6PKB8 Q96RN5
PDB IDs		2GUT 7EMF 7ENA 7ENC 7ENJ 7LBM 8GXQ 8GXS 8J9A 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Mesoderm Morphogenesis Pericardium Development Transcription Coactivator Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific SMAD Protein Complex Trophoblast Cell Migration Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Chromatin Binding Nucleobase-containing Compound Biosynthetic Process Embryonic Foregut Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Nodal Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Nucleoplasm Nucleus Liver Development Osteoblast Development I-SMAD Binding Ubiquitin Protein Ligase Binding Transforming Growth Factor Beta Receptor Binding Negative Regulation Of Cell Differentiation Negative Regulation Of Multicellular Organismal Process Double-stranded DNA Binding Protein-containing Complex Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Signal Transduction Response To Virus Response To Angiotensin R-SMAD Binding Negative Regulation Of MiRNA Transcription
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