MED15 and TRIM11

Number of citations of the paper that reports this interaction (PMID 16904669)
12

Data Source:
HPRD (in vivo)

		MED15	TRIM11
Gene Name		mediator complex subunit 15	tripartite motif containing 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Mediator Complex	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Ligase Activity Protein Domain Specific Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance	Protein Ubiquitination Negative Regulation Of Viral Transcription Innate Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Neurogenesis Defense Response To Virus Negative Regulation Of Viral Release From Host Cell
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ATP5C1 ATXN1 CTDP1 FHL3 MED25 MLLT6 PLSCR1 RELA SMAD2 SMAD3 TRIM11 UBC	6 interactors: MED15 PAX6 RNF126 TRIM27 TRIM29 TRIM35
Entrez ID		51586	81559
HPRD ID		12117	07429
Ensembl ID		ENSG00000099917	ENSG00000154370
Uniprot IDs		B4DGD6 G3V1P5 Q96RN5	Q96F44
PDB IDs		2GUT
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Primary MiRNA Processing RNA Biosynthetic Process DNA-templated Transcription, Initiation SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Paraxial Mesoderm Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Nodal Signaling Pathway Regulation Of Nucleic Acid-templated Transcription RNA Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Expression Regulation Of Viral Process Positive Regulation Of Chondrocyte Differentiation Pericardium Development Defense Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Negative Regulation Of Viral Release From Host Cell Regulation Of Viral Release From Host Cell Protein K63-linked Ubiquitination Retrograde Transport, Endosome To Golgi Negative Regulation Of Viral Process Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Glucagon Secretion Regulation Of Viral Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Rhombomere Morphogenesis Protein Polyubiquitination Transcription From RNA Polymerase II Promoter Regulation Of Asymmetric Cell Division Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spinal Cord Motor Neuron Fate Specification Positive Regulation Of Cell Fate Specification Transcription, DNA-templated Endosomal Transport Regulation Of Transcription From RNA Polymerase II Promoter Involved In Ventral Spinal Cord Interneuron Specification RNA Biosynthetic Process Pancreatic A Cell Differentiation Negative Regulation Of Calcium Ion Import Somatic Motor Neuron Differentiation Regulation Of Cellular Localization Stem Cell Development Forebrain Anterior/posterior Pattern Specification Cerebral Cortex Regionalization Negative Regulation Of Transcription, DNA-templated Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain Dorsal/ventral Pattern Formation Regulation Of Glucagon Secretion Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Interferon-gamma Secretion Oligodendrocyte Cell Fate Specification Lacrimal Gland Development Iris Morphogenesis Cornea Development In Camera-type Eye Rhombomere Development Stem Cell Differentiation Insulin Metabolic Process Negative Regulation Of Protein Phosphorylation Formation Of Anatomical Boundary Cellular Response To Prostaglandin E Stimulus
Tagcloud ?		9aatad 9aatads alignment ambiguous analogy architecture belong cmyb differently e2a formations foxo3 gcn4 heb helical kix leucine mll oaf1 pdr1 plausible position requirements resolved shares shed structural tad transactivation	adaptor antiviral cc cc2 collectively constitutively conversely defense dimerization ectopic ifnalpha ifnbeta infectivity innate interacted interferons irf3 knockdown mavs nap1 opposite phosphorylates rig sintbad tank tbk1 tightly traf tripartite
Tagcloud (Difference) ?		9aatad 9aatads alignment ambiguous analogy architecture belong cmyb differently e2a formations foxo3 gcn4 heb helical kix leucine mll oaf1 pdr1 plausible position requirements resolved shares shed structural tad transactivation	adaptor antiviral cc cc2 collectively constitutively conversely defense dimerization ectopic ifnalpha ifnbeta infectivity innate interacted interferons irf3 knockdown mavs nap1 opposite phosphorylates rig sintbad tank tbk1 tightly traf tripartite
Tagcloud (Intersection) ?