MBIP and CCNC

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MBIP	CCNC
Gene Name		MAP3K12 binding inhibitory protein 1	cyclin C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Cytoplasm	Nucleoplasm DNA-directed RNA Polymerase II, Holoenzyme Mediator Complex
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding	Protein Binding Protein Kinase Binding
	Biological Process	Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Chromatin Organization Histone H3 Acetylation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		41 interactors: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 CSRP2BP DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR2 ING5 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 STX11 TGIF2LY TXLNA TXLNB VPS28 VTA1 WDR5	32 interactors: CCNH CDK3 CDK8 CRX CTD DYDC1 ERCC3 ESR1 ESR2 FOXP2 GLYR1 GOLGA2 KRT13 KRT15 KRT31 LZTS2 MBIP MBP MCM2 MED8 MEOX2 MGST3 NEFL NMNAT1 PBXIP1 PNMA5 PUF60 RB1 TADA3 TP63 TRIM39 ZNF18
Entrez ID		51562	892
HPRD ID		14368	00456
Ensembl ID		ENSG00000151332	ENSG00000112237
Uniprot IDs		B2RCV0 Q9NS73	E5RFK5 P24863 Q7Z4L3
PDB IDs			3RGF 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L
Enriched GO Terms of Interacting Partners?		Organelle Organization Membrane Organization Histone H3 Acetylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Phosphorylation Histone Acetylation Establishment Of Localization In Cell Cellular Localization G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Establishment Of Endothelial Barrier Mitotic Cell Cycle Internal Protein Amino Acid Acetylation Secretion By Cell Protein Acetylation Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Exocyst Assembly Intermediate Filament-based Process Exocytosis Chromatin Modification Axon Cargo Transport Endothelial Cell Development	Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Intracellular Estrogen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Female Genitalia Development Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Prostate Gland Epithelium Morphogenesis Mitotic Cell Cycle Process Prostate Gland Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Development G1/S Transition Of Mitotic Cell Cycle Genitalia Development Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Neuron Death Prostate Gland Development Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Vagina Development Uterus Development Negative Regulation Of Gene Expression Cell Cycle Chromosome Organization Chromatin Organization Cell Cycle Process Epithelial Cell Differentiation Involved In Prostate Gland Development Cell Death Death Nucleotide-excision Repair, DNA Damage Removal Regulation Of Gene Expression
Tagcloud ?		advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotide oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility	aa ascorbic ccnd1 cyp7a1 den diethylnitrosamine drinking enhances ercc expressions fed hepatectomy hepatocellular hepatocytes icr initiation intraperitoneally ka kojic ppm proliferating proliferative removed sacrificed subjected surviving thirds week weights
Tagcloud (Difference) ?		advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotide oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility	aa ascorbic ccnd1 cyp7a1 den diethylnitrosamine drinking enhances ercc expressions fed hepatectomy hepatocellular hepatocytes icr initiation intraperitoneally ka kojic ppm proliferating proliferative removed sacrificed subjected surviving thirds week weights
Tagcloud (Intersection) ?