MBIP and LMO3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		MBIP	LMO3
Gene Name		MAP3K12 binding inhibitory protein 1	LIM domain only 3 (rhombotin-like 2)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Cytoplasm	Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding	Zinc Ion Binding
	Biological Process	Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Chromatin Organization Histone H3 Acetylation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		41 interactors: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 CSRP2BP DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR2 ING5 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 STX11 TGIF2LY TXLNA TXLNB VPS28 VTA1 WDR5	33 interactors: AIMP2 BANP CARF CCDC33 CCDC85B CEP170P1 CEP57L1 FAM131C FBLIM1 FOS GABPB1 HNRNPC HNRNPM IKZF1 KCTD1 KXD1 LDB1 LDB2 MBIP MDFI NBPF22P NHLH2 NUTM1 PHC2 RALYL RFX6 RORA SAMD3 SP4 SPERT TAX1BP1 ZBTB43 ZBTB8A
Entrez ID		51562	55885
HPRD ID		14368	11832
Ensembl ID		ENSG00000151332	ENSG00000048540
Uniprot IDs		B2RCV0 Q9NS73	Q8TAP4 Q9NYC6
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Membrane Organization Histone H3 Acetylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Phosphorylation Histone Acetylation Establishment Of Localization In Cell Cellular Localization G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Establishment Of Endothelial Barrier Mitotic Cell Cycle Internal Protein Amino Acid Acetylation Secretion By Cell Protein Acetylation Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Exocyst Assembly Intermediate Filament-based Process Exocytosis Chromatin Modification Axon Cargo Transport Endothelial Cell Development	RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cerebellar Purkinje Cell Differentiation Cerebellar Purkinje Cell Layer Morphogenesis Epithelial Structure Maintenance Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Metabolic Process Chromatin Modification Cerebellar Cortex Formation Cell Differentiation In Hindbrain Cerebellar Purkinje Cell Layer Development Cellular Metabolic Process Chromatin Organization Regulation Of Myeloid Cell Differentiation Cerebellar Cortex Morphogenesis Cellular Response To Calcium Ion Histone H3 Acetylation Positive Regulation Of Neutrophil Differentiation Histone H3-K4 Acetylation Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Pancreatic Epsilon Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Calcium Ion Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Pancreatic D Cell Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation
Tagcloud ?		advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotide oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility	aggressive aggressiveness atypical benign biosignatures clinically constitute decisions demand forty fourteen histologically igf1r meningioma meningiomas metabolic mostly nmr oligonucleotide otherwise predominant proceeds profiles recur recurrence relevance subgroup subgroups turnover
Tagcloud (Difference) ?		advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility	aggressive aggressiveness atypical benign biosignatures clinically constitute decisions demand forty fourteen histologically igf1r meningioma meningiomas metabolic mostly nmr otherwise predominant proceeds profiles recur recurrence relevance subgroup subgroups turnover
Tagcloud (Intersection) ?		oligonucleotide