MBIP and MAP3K12

Number of citations of the paper that reports this interaction (PMID 10801814)
10

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		MBIP	MAP3K12
Gene Name		MAP3K12 binding inhibitory protein 1	mitogen-activated protein kinase kinase kinase 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Cytoplasm	Cytoplasm Cytosol Plasma Membrane Membrane Axon Growth Cone
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity
	Biological Process	Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Chromatin Organization Histone H3 Acetylation	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		41 interactors: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 CSRP2BP DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR2 ING5 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 STX11 TGIF2LY TXLNA TXLNB VPS28 VTA1 WDR5	15 interactors: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP RGS1 RPL18A SH3RF1 TGM2 TSC22D1
Entrez ID		51562	7786
HPRD ID		14368	02709
Ensembl ID		ENSG00000151332	ENSG00000139625
Uniprot IDs		B2RCV0 Q9NS73	Q12852
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Membrane Organization Histone H3 Acetylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Phosphorylation Histone Acetylation Establishment Of Localization In Cell Cellular Localization G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Establishment Of Endothelial Barrier Mitotic Cell Cycle Internal Protein Amino Acid Acetylation Secretion By Cell Protein Acetylation Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Exocyst Assembly Intermediate Filament-based Process Exocytosis Chromatin Modification Axon Cargo Transport Endothelial Cell Development	MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JNK Cascade Regulation Of MAPK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Catalytic Activity Activation Of JUN Kinase Activity Cellular Response To Sorbitol Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Death Positive Regulation Of Transferase Activity Positive Regulation Of Apoptotic Process Activation Of Protein Kinase Activity Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Death Cellular Protein Metabolic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade
Tagcloud ?		advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotide oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility	adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper
Tagcloud (Difference) ?		advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotide oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility	adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper
Tagcloud (Intersection) ?