MBIP and COPS4

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MBIP	COPS4
Description		MAP3K12 binding inhibitory protein 1	COP9 signalosome subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Mitotic Spindle ATAC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction Cytoplasmic Vesicle Protein-containing Complex Synapse
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding	Protein Binding DeNEDDylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Regulation Of Embryonic Development Positive Regulation Of JNK Cascade Regulation Of Cell Division Regulation Of Cell Cycle	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation
Pathways		HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335 32769997)	Metabolite levels ( 23823483)
Interacting Genes		47 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR1 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SHANK3 SMARCB1 STX11 TGIF2LY TRIM55 TRIM63 TSC1 TXLNA TXLNB VPS28 VTA1 WDR5	28 interacting genes: BRME1 CCDC85B CEBPA COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 DSCR9 FOS GPS1 HUNK IKBKB IL1RN KRT19 LCOR MBIP PCDHB12 PEX14 RAB18 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ
Entrez ID		51562	51138
HPRD ID		14368	09888
Ensembl ID		ENSG00000151332	ENSG00000138663
Uniprot IDs		B2RCV0 Q9NS73	A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78
PDB IDs			4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Pore Localization Endosome Organization Positive Regulation Of GTPase Activity Cytoplasm Organelle Organization Positive Regulation Of Hydrolase Activity	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process COP9 Signalosome Assembly Protein Modification Process Intracellular Signaling Cassette Cytosol Regulation Of Primary Metabolic Process Negative Regulation Of Mitophagy Metal-dependent Deubiquitinase Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cul5-RING Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Cytokine-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor DNA-templated Transcription Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Stem Cell Proliferation Nucleus Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Histone Deacetylase Binding Nuclear Matrix Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Response To Glucocorticoid Cellular Response To Hypoxia Medium-term Memory Cellular Response To Prolactin Protein Metabolic Process Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity Peroxisome Transport Along Microtubule
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