UBD and UBA2

Number of citations of the paper that reports this interaction (PubMedID 31575873)
61

Data Source:
BioGRID (pull down)

		UBD	UBA2
Description		ubiquitin like modifier D	ubiquitin like modifier activating enzyme 2
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome	Nucleus Nucleoplasm Nucleolus Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	Protein Binding Proteasome Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Transferase Activity SUMO Activating Enzyme Activity SUMO Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Type II Interferon Response To Tumor Necrosis Factor Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Aggresome Assembly Regulation Of Mitotic Cell Cycle Phase Transition	Protein Sumoylation Positive Regulation Of Protein Sumoylation
Pathways		Neddylation	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Fish- and plant-related diet ( 32066663) Height ( 25429064) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		29 interacting genes: MAD2L1 NUB1 OTUB1 PDE9A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMD2 PSMD4 SAE1 SRPK1 SRPK2 TGFBR1 UBA2 UBA6 UBE2D2 UBE2Z USP16	19 interacting genes: BRIX1 CEBPA CHEK1 ERCC6 ETV4 MEOX2 NEDD8 PARK7 RAD23B SAE1 SERBP1 SETX SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBD UBE2I
Entrez ID		10537	10054
HPRD ID		09354	11658
Ensembl ID		ENSG00000213886	ENSG00000126261
Uniprot IDs		A0A1U9X8S6 O15205	Q9UBT2
PDB IDs		2MBE 6GF1 6GF2 7PYV 9E8O	1Y8Q 1Y8R 2PX9 3KYC 3KYD 4W5V 5FQ2 6CWY 6CWZ 6XOG 6XOH 6XOI
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Proteasome Core Complex, Alpha-subunit Complex Protein Catabolic Process Protein Metabolic Process Proteasome Core Complex, Beta-subunit Complex Nucleoplasm Catabolic Process Macromolecule Metabolic Process Nucleus Cytosol Extracellular Exosome Threonine-type Endopeptidase Activity Ubiquitin-like Modifier Activating Enzyme Activity Secretory Granule Lumen Ficolin-1-rich Granule Lumen SUMO Activating Enzyme Activity SUMO Activating Enzyme Complex Cytoplasm Ubiquitin Activating Enzyme Activity Endopeptidase Activity Small Protein Activating Enzyme Binding Protein Modification Process Post-translational Protein Modification Proteasome Regulatory Particle, Base Subcomplex Positive Regulation Of Protein Sumoylation Proteasome Accessory Complex P-body Regulation Of Protein Sumoylation Regulation Of Post-translational Protein Modification Peptidase Activity Protein Modification By Small Protein Conjugation Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ubiquitin Conjugating Enzyme Activity Lipopolysaccharide Binding Purine Ribonucleoside Triphosphate Binding Positive Regulation Of Ribosome Biogenesis FAT10 Activating Enzyme Activity Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication	Protein Tag Activity Small Protein Activating Enzyme Binding Protein Sumoylation Protein Modification By Small Protein Conjugation PML Body Post-translational Protein Modification Nucleus Ubiquitin-like Protein Ligase Binding PML Body Organization Protein Modification Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Macromolecule Metabolic Process Protein Metabolic Process Nuclear Body Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Nucleus Organization Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Metabolic Process DNA Repair Regulation Of Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Binding DNA Damage Response Proteasome Binding Negative Regulation Of DNA Binding Ubiquitin-specific Protease Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Sumoylation Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Nucleolus Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Metabolic Process
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