MAGEC2 and PBX3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MAGEC2	PBX3
Description		MAGE family member C2	PBX homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity	Eye Development Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Anterior Compartment Pattern Formation Posterior Compartment Specification Brain Development Respiratory Gaseous Exchange By Respiratory System Adult Locomotory Behavior Animal Organ Morphogenesis Dorsal Spinal Cord Development Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development
Pathways
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Non-response to bupropion and depression ( 27622933)	Dentures ( 31235808) Fish- and plant-related diet ( 32066663) Medication use (opioids) ( 31015401) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pulse pressure ( 30578418) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to mTOR inhibitor (everolimus) ( 24009623) Sleep duration ( 30531941) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		15 interacting genes: MDM2 MNAT1 P4HA3 PBX3 PCGF6 RBX1 RNF166 SSX1 SSX2 TAF9 TRAF4 TRIM28 TRIM8 UBR3 ZMYND11	65 interacting genes: AGTRAP ARFIP2 ARL6IP1 BIK BSND CAV3 CFTR CIDEB CMTM4 CMTM5 COQ8A CPLX2 DESI2 DGAT2L6 FADS6 FAM177A1 FKBP7 FSD2 GAD2 GBP7 HIGD1C HOXA9 HOXB8 HSD17B13 INPP5K INSYN1 ITGB3BP KRT27 KRT31 LIME1 MAGEA1 MAGEC2 MAL2 MBLAC2 MDK MEIS1 MICOS13 MTERF3 NUDT9 PKNOX1 PLIN3 PRB3 PTPN9 RABAC1 REEP5 RHBDD2 RHEX RNF186 RPRM SCAMP1 SFT2D2 SIN3A SMPD2 SYP SYPL1 TFIP11 TMCO2 TMEM196 TPD52L1 TPM3 TRAF1 TRIM44 TVP23B ZNF655 ZNHIT3
Entrez ID		51438	5090
HPRD ID		06632	15938
Ensembl ID		ENSG00000046774	ENSG00000167081
Uniprot IDs		Q9UBF1	P40426 Q5JS98 Q96AL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Regulation Of Primary Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Modification-dependent Protein Catabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Metal Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Post-translational Protein Modification Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Suppression Of Viral Release By Host Ubiquitin Protein Ligase Binding SUMO Transferase Activity Protein Ubiquitination Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Macromolecule Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Gene Expression Respiratory Gaseous Exchange By Respiratory System Proteolysis Transferase Activity Regulation Of Macromolecule Biosynthetic Process Response To Stress DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Transcription By RNA Polymerase II Regulation Of Proteasomal Protein Catabolic Process Transcription Corepressor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Apoptotic Process	Protein Binding
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