MAGEC2 and UBR3

Number of citations of the paper that reports this interaction (PubMedID 25590999)
60

Data Source:
BioGRID (two hybrid)

		MAGEC2	UBR3
Description		MAGE family member C2	ubiquitin protein ligase E3 component n-recognin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Ubiquitin Ligase Complex Cytoplasm Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity	In Utero Embryonic Development Suckling Behavior Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Smell Embryo Development Ending In Birth Or Egg Hatching Protein Ubiquitination Olfactory Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Non-response to bupropion and depression ( 27622933)	Longitudinal change in brain amyloid plaque burden ( 26268530) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Urate levels in obese individuals ( 25811787)
Interacting Genes		15 interacting genes: MDM2 MNAT1 P4HA3 PBX3 PCGF6 RBX1 RNF166 SSX1 SSX2 TAF9 TRAF4 TRIM28 TRIM8 UBR3 ZMYND11	7 interacting genes: APEX1 DZIP3 MAGEC2 UBE2A UBE2B UBE2D2 UBE2H
Entrez ID		51438	130507
HPRD ID		06632	15887
Ensembl ID		ENSG00000046774	ENSG00000144357
Uniprot IDs		Q9UBF1	Q6ZT12
PDB IDs
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Regulation Of Primary Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Modification-dependent Protein Catabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Metal Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Post-translational Protein Modification Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Suppression Of Viral Release By Host Ubiquitin Protein Ligase Binding SUMO Transferase Activity Protein Ubiquitination Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Macromolecule Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Gene Expression Respiratory Gaseous Exchange By Respiratory System Proteolysis Transferase Activity Regulation Of Macromolecule Biosynthetic Process Response To Stress DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Transcription By RNA Polymerase II Regulation Of Proteasomal Protein Catabolic Process Transcription Corepressor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Apoptotic Process	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Macromolecule Catabolic Process HULC Complex Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Postreplication Repair Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification Process Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Transferase Activity Protein Autoubiquitination Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA-(abasic Site) Binding Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity Macromolecule Metabolic Process Positive Regulation Of Reciprocal Meiotic Recombination Proteasomal Protein Catabolic Process Proteolysis DNA Repair Uracil DNA N-glycosylase Activity Phosphodiesterase I Activity ATP Binding Response To UV Double-stranded DNA 3'-5' DNA Exonuclease Activity Chiasma Assembly RNA-DNA Hybrid Ribonuclease Activity BBSome DNA Metabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Double-stranded Telomeric DNA Binding Telomere Localization DNA Damage Response 3'-5'-DNA Exonuclease Activity Nucleotide Binding
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