EIF3L and POLR1B

Number of citations of the paper that reports this interaction (PubMedID 11592397)
0

Data Source:
HPRD (in vitro)

		EIF3L	POLR1B
Description		eukaryotic translation initiation factor 3 subunit L	RNA polymerase I subunit B
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Protein-containing Complex Eukaryotic 48S Preinitiation Complex Synapse	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Cytosol
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleoside Binding 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Viral Translational Termination-reinitiation	DNA-templated Transcription Embryo Implantation RRNA Transcription Neural Crest Formation Nucleologenesis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: DNM2 EIF3D EIF3E EIF3K ERCC6 HRAS POLR1B PPP1R18 RGS2 RRN3 SMAD2 SNCA XRN2	14 interacting genes: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207
Entrez ID		51386	84172
HPRD ID		10932	06852
Ensembl ID		ENSG00000100129	ENSG00000125630
Uniprot IDs		B0QY90 Q9Y262	B7Z1W6 Q9H9Y6
PDB IDs		3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN	7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 43S Preinitiation Complex Macromolecule Biosynthetic Process Cytoplasmic Translational Initiation Translation Initiation Factor Activity Nucleolus Organization Translational Initiation RNA Polymerase Binding Protein-containing Complex Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Protein-containing Complex Organization Regulation Of Gene Expression RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Synaptic Vesicle Transport Nucleolus Fibroblast Proliferation Protein-RNA Complex Assembly Beta-tubulin Binding Tau Protein Binding Response To Gamma Radiation Phosphatase Binding Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Gene Expression Negative Regulation Of Membrane Tubulation Receptor Internalization Vesicle Scission Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein GTPase Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Homomeric SMAD Protein Complex Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Transcription Termination Site Sequence-specific DNA Binding Nucleologenesis	Macromolecule Biosynthetic Process Transcription Preinitiation Complex Assembly Nucleoplasm DNA-templated Transcription Protein-DNA Complex Assembly Transcription Initiation At RNA Polymerase I Promoter RNA Polymerase I Preinitiation Complex Assembly Nucleobase-containing Compound Biosynthetic Process Regulation Of Intracellular Signal Transduction Protein-containing Complex Organization Mammary Gland Epithelial Cell Proliferation Response To Corticosterone Mammary Gland Alveolus Development Macromolecule Metabolic Process Cellular Component Assembly Enzyme Binding Protein-containing Complex Protein-containing Complex Assembly Response To Mineralocorticoid RNA Metabolic Process Fibroblast Proliferation Cellular Response To High Light Intensity RNA Polymerase II Preinitiation Complex Assembly Transcription Corepressor Binding Spindle Matrix Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Signal Transduction Cell Leading Edge Response To High Light Intensity Response To Hormone Retinal Rod Cell Apoptotic Process Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Response To Estrogen Transcription By RNA Polymerase II Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity DNA-templated Transcription Initiation Cellular Response To Hormone Stimulus Positive Regulation Of Cap-dependent Translational Initiation
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