EIF3L and DNM2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		EIF3L	DNM2
Gene Name		eukaryotic translation initiation factor 3, subunit L	dynamin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Microtubule Plasma Membrane Coated Pit Focal Adhesion Postsynaptic Density Growth Cone Midbody Endocytic Vesicle Membrane Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translational Initiation	G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitric Oxide Metabolic Process Synaptic Vesicle Transport Neuron Projection Morphogenesis Regulation Of Nitric-oxide Synthase Activity Membrane Organization Negative Regulation Of Membrane Tubulation
Pathways			Retrograde neurotrophin signalling Axon guidance Gap junction degradation Golgi Associated Vesicle Biogenesis L1CAM interactions Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Metabolism of nitric oxide Gap junction trafficking and regulation NOSTRIN mediated eNOS trafficking MHC class II antigen presentation eNOS activation and regulation trans-Golgi Network Vesicle Budding Innate Immune System Formation of annular gap junctions Signalling by NGF Gap junction trafficking NGF signalling via TRKA from the plasma membrane Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Adaptive Immune System
Drugs
Diseases
GWAS			Coronary heart disease ( 21347282)
Protein-Protein Interactions		9 interactors: DNM2 EIF3D EIF3E EIF3K POLR1B RGS2 RRN3 SMAD2 XRN2	52 interactors: AMPH AOC1 AP2A1 APP ATF7IP ATXN3 BIN1 CCDC90B CCR5 CCT7 CDK1 CTTN DDX39B DNM1 DYNC1I1 DYNLL1 EIF3L EPS15 FNBP1 FNBP1L GDF9 GRB2 HCK HMGB1 ITSN1 ITSN2 KDR MAN1B1 MANEA MPHOSPH6 MPP6 PDE6G PFN1 PPIB PSTPIP1 PTK2 RPS2 RWDD2B SH3GL2 SH3GLB1 SHANK1 SHANK2 SNX9 SPRY2 SRC TIAM2 TRIP10 TYK2 VAV1 WBP4 ZBTB16 ZFAND6
Entrez ID		51386	1785
HPRD ID		10932	03852
Ensembl ID		ENSG00000100129	ENSG00000079805
Uniprot IDs		B0QY90 Q9Y262	P50570 Q8N1K8
PDB IDs			2YS1
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Nucleolus Organization Regulation Of Translational Initiation Regulation Of Translation Ribonucleoprotein Complex Biogenesis Ribonucleoprotein Complex Assembly Regulation Of Metabolic Process Gene Expression Transcription Initiation From RNA Polymerase I Promoter Cellular Macromolecule Biosynthetic Process Cellular Macromolecular Complex Assembly Macromolecule Biosynthetic Process Translational Initiation Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Initiation DNA-templated Transcription, Termination Biosynthetic Process Nucleologenesis Negative Regulation Of Membrane Tubulation Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Formation Of Cytoplasmic Translation Initiation Complex Nucleus Organization Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Translation RNA Catabolic Process Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Positive Regulation Of Cardiac Muscle Contraction Regulation Of Gene Expression, Epigenetic Cytoplasmic Translational Initiation Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Activin Receptor Signaling Pathway Cytoplasm Organization Negative Regulation Of Phospholipase Activity RNA Metabolic Process Relaxation Of Vascular Smooth Muscle Cellular Component Assembly Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy SMAD Protein Complex Assembly	Endocytosis Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Growth Factor Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Organic Substance Chemotaxis Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling Transport Neurotrophin TRK Receptor Signaling Pathway Viral Process Positive Regulation Of Cellular Component Biogenesis Peptidyl-tyrosine Autophosphorylation Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of ERBB Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Protein Complex Assembly Neuron Projection Development Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cellular Component Organization Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Catalytic Activity Response To Organic Substance Nervous System Development Neuron Development Cell Projection Organization Response To External Stimulus Apoptotic Process Cellular Component Assembly Programmed Cell Death Cell Migration Immune System Process Axonogenesis Cell Death
Tagcloud ?		biologically chromatography complex complexes composed consisting coupled devoid efficient encoding eukaryotic feasible hela incubation initiation native nonessential plasmids prepare programmed rapid reconstitute reconstituted reconstitution subunits system tag translation	bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		biologically chromatography complex complexes composed consisting coupled devoid efficient encoding eukaryotic feasible hela incubation initiation native nonessential plasmids prepare programmed rapid reconstitute reconstituted reconstitution subunits system tag translation	bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?