EIF3L and RRN3

Number of citations of the paper that reports this interaction (PMID 15004009)
81

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		EIF3L	RRN3
Gene Name		eukaryotic translation initiation factor 3, subunit L	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding	RNA Polymerase Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translational Initiation	In Utero Embryonic Development Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Gene Expression Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation
Pathways			RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: DNM2 EIF3D EIF3E EIF3K POLR1B RGS2 RRN3 SMAD2 XRN2	10 interactors: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C
Entrez ID		51386	54700
HPRD ID		10932	12004
Ensembl ID		ENSG00000100129	ENSG00000085721
Uniprot IDs		B0QY90 Q9Y262	F5H148 Q9NYV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Nucleolus Organization Regulation Of Translational Initiation Regulation Of Translation Ribonucleoprotein Complex Biogenesis Ribonucleoprotein Complex Assembly Regulation Of Metabolic Process Gene Expression Transcription Initiation From RNA Polymerase I Promoter Cellular Macromolecule Biosynthetic Process Cellular Macromolecular Complex Assembly Macromolecule Biosynthetic Process Translational Initiation Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Initiation DNA-templated Transcription, Termination Biosynthetic Process Nucleologenesis Negative Regulation Of Membrane Tubulation Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Formation Of Cytoplasmic Translation Initiation Complex Nucleus Organization Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Translation RNA Catabolic Process Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Positive Regulation Of Cardiac Muscle Contraction Regulation Of Gene Expression, Epigenetic Cytoplasmic Translational Initiation Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Activin Receptor Signaling Pathway Cytoplasm Organization Negative Regulation Of Phospholipase Activity RNA Metabolic Process Relaxation Of Vascular Smooth Muscle Cellular Component Assembly Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy SMAD Protein Complex Assembly	Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Chromatin Silencing At RDNA Chromatin Silencing Gene Silencing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RRNA Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Expression Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Nucleologenesis RNA Metabolic Process RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Mitotic Cell Cycle Process Post-embryonic Hemopoiesis Nucleolus Organization Cellular Metabolic Process Mitotic Cell Cycle Regulation Of DNA-dependent DNA Replication Initiation Mitotic Nuclear Envelope Reassembly Glomerular Visceral Epithelial Cell Development Regulation Of Tight Junction Assembly Metabolic Process Nuclear Envelope Reassembly
Tagcloud ?		biologically chromatography complex complexes composed consisting coupled devoid efficient encoding eukaryotic feasible hela incubation initiation native nonessential plasmids prepare programmed rapid reconstitute reconstituted reconstitution subunits system tag translation	architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated
Tagcloud (Difference) ?		biologically chromatography complex complexes composed consisting coupled devoid efficient encoding eukaryotic feasible hela incubation initiation native nonessential plasmids prepare programmed rapid reconstitute reconstituted reconstitution system tag translation	architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 tata tbp tfiib upstream validated
Tagcloud (Intersection) ?		subunits