ATP6V1D and NDC80

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V1D	NDC80
Description		ATPase H+ transporting V1 subunit D	NDC80 kinetochore complex component
Image
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Cytoplasm Lysosomal Membrane Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Specific Granule Membrane Cell Projection Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Membrane Nuclear Speck Ndc80 Complex
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding Microtubule Binding Cyclin Binding Identical Protein Binding Kinetochore Adaptor Activity
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Cell Projection Organization Endosomal Lumen Acidification Intracellular PH Reduction Cilium Assembly Protein Localization To Cilium Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Division Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling G2/MI Transition Of Meiotic Cell Cycle Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Chromosome Organization Centrosome Duplication Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Nuclear Chromosome Segregation
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Tiludronic acid
Diseases
GWAS			Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		6 interacting genes: GOLGA2 HAUS1 KRT27 NDC80 TOMM34 VPS52	57 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CEP63 CIP2A CKAP5 EXOC8 GOLGA2 HAUS1 HGS IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PPP1R13B PSMC2 RB1 SFR1 SKA1 SKA3 SMC1A SPC25 STX11 TFIP11 THOC7 TOM1L1 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT
Entrez ID		51382	10403
HPRD ID		16524	06277
Ensembl ID		ENSG00000100554	ENSG00000080986
Uniprot IDs		Q9Y5K8	A8K031 O14777
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF	2IGP 2VE7 3IZ0 8G0P
Enriched GO Terms of Interacting Partners?		Spindle Assembly Meiotic Spindle Assembly Spindle Organization Meiotic Spindle Organization Membraneless Organelle Assembly Syntaxin Binding Centrosome Cycle Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Organizing Center Organization Cell Division Embryonic Ectodermal Digestive Tract Development Kinetochore Adaptor Activity Mitotic Spindle Organization G2/MI Transition Of Meiotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Protein Glycosylation Spindle Pole Organelle Assembly Meiotic Cell Cycle Phase Transition Ndc80 Complex Spindle Assembly Involved In Female Meiosis I GARP Complex EARP Complex Ectodermal Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Microtubule-based Process Golgi Disassembly Protein Targeting Regulation Of Protein Glycosylation Vesicle-mediated Cholesterol Transport HAUS Complex Microtubule Binding Importin-alpha Family Protein Binding Golgi Ribbon Formation Skeletal Muscle Cell Proliferation Golgi Cis Cisterna Golgi Vesicle Transport Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Assembly Involved In Female Meiosis Asymmetric Cell Division Organelle Organization Microtubule Mitotic Spindle Microtubule Positive Regulation Of Glycoprotein Metabolic Process Establishment Of Protein Localization Positive Regulation Of Glycoprotein Biosynthetic Process Golgi To Vacuole Transport Embryonic Digestive Tract Development Outer Kinetochore	Kinetochore Cell Division Chromosome, Centromeric Region Organelle Organization Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Centrosome Regulation Of Chromosome Separation Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Microtubule-based Process Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Mitotic Sister Chromatid Segregation Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Sister Chromatid Segregation Regulation Of Sister Chromatid Segregation Spindle Pole Cytoskeleton Organization Regulation Of Chromosome Segregation Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Chromosome Spindle Regulation Of Chromosome Organization Positive Regulation Of Mitotic Sister Chromatid Separation Organelle Assembly Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Process Microtubule Chromosome Organization Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cell Cycle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?