ATP6V1D and VPS52

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V1D	VPS52
Description		ATPase H+ transporting V1 subunit D	VPS52 subunit of GARP complex
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Cytoplasm Lysosomal Membrane Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Specific Granule Membrane Cell Projection Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane	GARP Complex Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse EARP Complex
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding Syntaxin Binding
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Cell Projection Organization Endosomal Lumen Acidification Intracellular PH Reduction Cilium Assembly Protein Localization To Cilium Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Protein Targeting Golgi To Vacuole Transport Lysosomal Transport Ectodermal Cell Differentiation Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Embryonic Ectodermal Digestive Tract Development Vesicle-mediated Cholesterol Transport
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Retrograde transport at the Trans-Golgi-Network
Drugs		Tiludronic acid
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971)
Interacting Genes		6 interacting genes: GOLGA2 HAUS1 KRT27 NDC80 TOMM34 VPS52	101 interacting genes: AAMP AIRIM ARNT2 ATP6V1D BYSL C1orf216 CABP5 CACNA1A CATSPERT CCDC102B CCDC13 CCDC146 CCDC185 CCDC187 CCDC33 CCDC57 CCHCR1 CDC20B CDC5L CDK18 CEP19 CFAP206 CWF19L2 DCX DDX6 DNAJC11 DTNB EPM2AIP1 FAM110A FAM161A FAM161B FAM184A FAM50B GEM GFM2 GOLGA1 GORASP2 GPKOW HAUS1 HDAC4 HEATR1 HGS HOXB5 JAKMIP2 KANK2 KIAA1217 KIF5B KIF9 KIFC3 KLC3 KLHL42 LMO4 LNX1 MAGEL2 MAPK3 METTL13 MFAP1 MRPL1 MRPL11 NDC80 NFKBIB NOP2 NR2C2AP OTUD6A PIMREG PKN3 PPP1R18 PRKAA1 PRKAA2 RAB4A RAB4B RABEP2 RUNX1T1 SCNM1 SH2D4A SMARCE1 STX11 TAB2 TBC1D1 TBC1D22B TCEANC TCP11L1 TEAD4 THAP11 TPM3 TRAF4 TRAF6 TSSK3 TSTD2 TXLNB TXN2 USP2 VEZF1 VPS28 VPS53 WASHC3 WTAP ZC2HC1C ZMAT2 ZNF417 ZNF587
Entrez ID		51382	6293
HPRD ID		16524	09142
Ensembl ID		ENSG00000100554	ENSG00000223501
Uniprot IDs		Q9Y5K8	A0A1U9X8S4 B3KMF7 B4DS44 Q4VXZ2 Q8N1B4
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Spindle Assembly Meiotic Spindle Assembly Spindle Organization Meiotic Spindle Organization Membraneless Organelle Assembly Syntaxin Binding Centrosome Cycle Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Organizing Center Organization Cell Division Embryonic Ectodermal Digestive Tract Development Kinetochore Adaptor Activity Mitotic Spindle Organization G2/MI Transition Of Meiotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Protein Glycosylation Spindle Pole Organelle Assembly Meiotic Cell Cycle Phase Transition Ndc80 Complex Spindle Assembly Involved In Female Meiosis I GARP Complex EARP Complex Ectodermal Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Microtubule-based Process Golgi Disassembly Protein Targeting Regulation Of Protein Glycosylation Vesicle-mediated Cholesterol Transport HAUS Complex Microtubule Binding Importin-alpha Family Protein Binding Golgi Ribbon Formation Skeletal Muscle Cell Proliferation Golgi Cis Cisterna Golgi Vesicle Transport Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Assembly Involved In Female Meiosis Asymmetric Cell Division Organelle Organization Microtubule Mitotic Spindle Microtubule Positive Regulation Of Glycoprotein Metabolic Process Establishment Of Protein Localization Positive Regulation Of Glycoprotein Biosynthetic Process Golgi To Vacuole Transport Embryonic Digestive Tract Development Outer Kinetochore	Protein Binding Cytoskeleton Organelle Assembly Centrosome Microtubule Binding Microtubule-based Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Organelle Organization Organelle Disassembly Ciliary Basal Body Kinesin Complex Protein Localization To Lipid Droplet Protein Localization To Vacuole Microtubule Cytoskeleton Organization Protein Localization To Lysosome Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Insulin-responsive Compartment Centriole
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