HOOK1 and MYSM1

		HOOK1	MYSM1
Description		hook microtubule tethering protein 1	Myb like, SWIRM and MPN domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton HOPS Complex FHF Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Dynein Light Intermediate Chain Binding	DNA Binding Transcription Coactivator Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Histone Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity Histone H2A Deubiquitinase Activity
	Biological Process	Golgi Organization Endosome Organization Lysosome Organization Spermatogenesis Spermatid Development Endosome To Lysosome Transport Protein Transport Cell Differentiation Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly Protein Localization To Perinuclear Region Of Cytoplasm	Immune System Process Chromatin Organization Chromatin Remodeling Proteolysis Regulation Of Cell Migration Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hair Follicle Development Regulation Of Hemopoiesis
Pathways			Metalloprotease DUBs
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Diabetic retinopathy ( 21310492) Metabolite levels ( 23823483) Nickel levels ( 26025379) Night sleep phenotypes ( 27126917)
Interacting Genes		46 interacting genes: AKTIP ANK3 ANKRD23 AP1M1 AP4M1 CCDC9 CDC5L CDK4 CUL1 CWF19L2 DENND1B ESS2 EXOSC7 FAM161A FHIP1B HNRNPLL HOOK2 HOOK3 KAT5 LENG1 LMO2 MEOX2 PIAS2 PRPF6 RBM22 RNF10 RPS7 SNW1 TBC1D7 TFIP11 UNKL USP2 UTP14A UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80	3 interacting genes: H2AC20 MPP7 STING1
Entrez ID		51361	114803
HPRD ID		07428	13903
Ensembl ID		ENSG00000134709	ENSG00000162601
Uniprot IDs		Q9UJC3	A0A590UJW2 Q5VVJ2
PDB IDs			2CU7 2DCE
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport Vacuolar Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Lysosome Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Catalytic Step 2 Spliceosome Vesicle Organization Early Endosome To Late Endosome Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Clathrin-coated Vesicle AP-3 Adaptor Complex Endosome Organization RNA Processing Regulation Of Transcription By RNA Polymerase II Lysosomal HOPS Complex Protein Transport Endosomal Transport Spliceosomal Complex MRNA Processing Establishment Of Protein Localization MRNA Metabolic Process Zinc Ion Binding RNA Splicing U2-type Catalytic Step 2 Spliceosome Vesicle-mediated Transport Nucleus Intracellular Transport Regulation Of Macromolecule Metabolic Process RNA Metabolic Process CORVET Complex Regulation Of Gene Expression Vesicle Fusion Regulation Of Metabolic Process Nuclear Speck Organelle Membrane Fusion Regulation Of DNA-templated Transcription Positive Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Localization Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Protein Targeting To Vacuole Clathrin Adaptor Complex	Signaling Adaptor Activity Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Vacuole Organization FHF Complex Protein Localization To Adherens Junction MPP7-DLG1-LIN7 Complex Protein Localization To Perinuclear Region Of Cytoplasm Manchette Assembly Proton Channel Activity Positive Regulation Of CGAS/STING Signaling Pathway
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