PIGF and LYVE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIGF	LYVE1
Description		phosphatidylinositol glycan anchor biosynthesis class F	lymphatic vessel endothelial hyaluronan receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane Extracellular Exosome Cell Periphery
	Molecular Function	Ethanolaminephosphotransferase Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Hyaluronic Acid Binding Signaling Receptor Activity Cargo Receptor Activity
	Biological Process	GPI Anchor Biosynthetic Process	Positive Regulation Of Cellular Extravasation Glycosaminoglycan Catabolic Process Receptor-mediated Endocytosis Cell Adhesion Cell-matrix Adhesion Response To Wounding Anatomical Structure Morphogenesis Hyaluronan Catabolic Process
Pathways		Synthesis of glycosylphosphatidylinositol (GPI) Synthesis of glycosylphosphatidylinositol (GPI)	Hyaluronan metabolism Hyaluronan degradation
Drugs			Hyaluronic acid
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20966902) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood protein levels ( 30072576)
Interacting Genes		10 interacting genes: AQP6 GPR152 LYVE1 MANBAL PIGG PIGO TIMMDC1 TMEM130 TMEM14B TMEM86B	26 interacting genes: AIG1 AQP10 CLCN7 CYSRT1 EMP3 KRT34 KRTAP10-3 KRTAP10-8 KRTAP12-3 KRTAP6-2 KRTAP9-2 NBPF19 NINJ2 NOTCH2NLA NRSN1 PDGFB PIGF SERP2 SLC30A2 SLC38A7 SLC41A2 THSD7A THSD7B UBE2J1 VEGFA YIPF6
Entrez ID		5281	10894
HPRD ID		02539	05753
Ensembl ID		ENSG00000151665	ENSG00000133800
Uniprot IDs		H7C392 Q07326 Q6IB04	B2R672 Q9Y5Y7
PDB IDs			8OS2 8OXD
Enriched GO Terms of Interacting Partners?		Mannose-ethanolamine Phosphotransferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Membrane GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycerophospholipid Metabolic Process Nitrate Transmembrane Transporter Activity Glycolipid Biosynthetic Process Glycerolipid Metabolic Process CP2 Mannose-ethanolamine Phosphotransferase Activity D-lysine 5,6-aminomutase Activity Phospholipid Metabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Glycerophospholipid Biosynthetic Process Monoatomic Anion Channel Activity Renal Water Transport Ammonium Channel Activity Mitochondrial Membrane Membrane Lipid Metabolic Process Ammonium Transmembrane Transport Phospholipid Biosynthetic Process Hyaluronan Catabolic Process Water Channel Activity Phosphatidylcholine Acyl-chain Remodeling Carbon Dioxide Transport Carbohydrate Derivative Metabolic Process Transferase Activity, Transferring Phosphorus-containing Groups Positive Regulation Of Cellular Extravasation	Intermediate Filament Keratin Filament Positive Regulation Of Protein Autophosphorylation Regulation Of Protein Autophosphorylation Platelet-derived Growth Factor Receptor Binding Monoatomic Cation Transmembrane Transporter Activity
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