PIGF and PIGO

Number of citations of the paper that reports this interaction (PubMedID 10781593)
0

Data Source:
HPRD (in vivo)

		PIGF	PIGO
Description		phosphatidylinositol glycan anchor biosynthesis class F	phosphatidylinositol glycan anchor biosynthesis class O
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Ethanolaminephosphotransferase Activity Protein Binding	Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Phosphotransferase Activity, For Other Substituted Phosphate Groups Mannose-ethanolamine Phosphotransferase Activity
	Biological Process	GPI Anchor Biosynthetic Process	GPI Anchor Biosynthetic Process
Pathways		Synthesis of glycosylphosphatidylinositol (GPI) Synthesis of glycosylphosphatidylinositol (GPI)	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20966902) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Response to quetiapine in schizophrenia ( 29503163) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		10 interacting genes: AQP6 GPR152 LYVE1 MANBAL PIGG PIGO TIMMDC1 TMEM130 TMEM14B TMEM86B	2 interacting genes: APP PIGF
Entrez ID		5281	84720
HPRD ID		02539	15134
Ensembl ID		ENSG00000151665	ENSG00000165282
Uniprot IDs		H7C392 Q07326 Q6IB04	Q8TEQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Mannose-ethanolamine Phosphotransferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Membrane GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycerophospholipid Metabolic Process Nitrate Transmembrane Transporter Activity Glycolipid Biosynthetic Process Glycerolipid Metabolic Process CP2 Mannose-ethanolamine Phosphotransferase Activity D-lysine 5,6-aminomutase Activity Phospholipid Metabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Glycerophospholipid Biosynthetic Process Monoatomic Anion Channel Activity Renal Water Transport Ammonium Channel Activity Mitochondrial Membrane Membrane Lipid Metabolic Process Ammonium Transmembrane Transport Phospholipid Biosynthetic Process Hyaluronan Catabolic Process Water Channel Activity Phosphatidylcholine Acyl-chain Remodeling Carbon Dioxide Transport Carbohydrate Derivative Metabolic Process Transferase Activity, Transferring Phosphorus-containing Groups Positive Regulation Of Cellular Extravasation	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Perinuclear Region Of Cytoplasm Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Low-density Lipoprotein Particle Mediated Signaling Collagen Type XV Trimer Phosphorylase Kinase Complex Phosphorylase Kinase Activity Positive Regulation Of Glycogen Catabolic Process Ethanolaminephosphotransferase Activity Microtubule-based Process Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Glycogen Catabolic Process Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen
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