PCYT1A and CASP6

Number of citations of the paper that reports this interaction (PMID 12052891)
20

Data Source:
HPRD (in vitro, in vivo)

		PCYT1A	CASP6
Gene Name		phosphate cytidylyltransferase 1, choline, alpha	caspase 6, apoptosis-related cysteine peptidase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Glycogen Granule	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Choline-phosphate Cytidylyltransferase Activity Lipid Binding Protein Homodimerization Activity	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation
Pathways		Synthesis of PC Metabolism of lipids and lipoproteins Phospholipid metabolism Glycerophospholipid biosynthesis	Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Breakdown of the nuclear lamina Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Choline
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ACTB CASP6 CASP8	38 interactors: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM
Entrez ID		5130	839
HPRD ID		00438	03321
Ensembl ID		ENSG00000161217	ENSG00000138794
Uniprot IDs		P49585	P55212
PDB IDs			1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA
Enriched GO Terms of Interacting Partners?		Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development TRAIL-activated Apoptotic Signaling Pathway Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Macrophage Differentiation Single Organismal Cell-cell Adhesion Response To Cobalt Ion Negative Regulation Of Necroptotic Process Negative Regulation Of Necrotic Cell Death Regulation Of Necroptotic Process Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Immune Response Hepatocyte Apoptotic Process Macrophage Differentiation Cell Activation Regulation Of Necrotic Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cell Differentiation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Innate Immune Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Immune Response Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Immune System Process Cell Differentiation Involved In Embryonic Placenta Development Substantia Nigra Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process Platelet Aggregation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Regulation Of T Cell Apoptotic Process Cell Death Death Epithelium Development Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Myeloid Leukocyte Differentiation Neural Nucleus Development Response To Cold Response To Antibiotic 'de Novo' Posttranslational Protein Folding Positive Regulation Of Mitochondrion Organization Labyrinthine Layer Development Cell Adhesion Regulation Of Lymphocyte Apoptotic Process Retina Homeostasis 'de Novo' Protein Folding Natural Killer Cell Activation	Programmed Cell Death Cell Death Death Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Viral Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Tissue Development Response To Stimulus Heart Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Signaling Signaling Regulation Of Cell Death Anatomical Structure Morphogenesis Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Neuron Death Skin Development Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Myeloid Cell Differentiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Organ Development Cell Differentiation Cellular Response To Stimulus Response To Stress Signal Transduction Positive Regulation Of Catalytic Activity Cell Development Positive Regulation Of Proteolysis Immune System Process Regulation Of Phosphorylation Anatomical Structure Development Cellular Response To Organic Substance
Tagcloud ?		actb barr choices clk2 cops5 dataset deltadeltact deviation ebv epstein fibroblasts gapdh genorm gusb hprt1 interest lcls lymphoblastoid normalization normfinder ppib quantification rad51l1 ranked reference rnf10 rnf111 tfrc threshold	5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin
Tagcloud (Difference) ?		actb barr choices clk2 cops5 dataset deltadeltact deviation ebv epstein fibroblasts gapdh genorm gusb hprt1 interest lcls lymphoblastoid normalization normfinder ppib quantification rad51l1 ranked reference rnf10 rnf111 tfrc threshold	5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin
Tagcloud (Intersection) ?