PCYT1A and PCYT1B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PCYT1A	PCYT1B
Description		phosphate cytidylyltransferase 1A, choline	phosphate cytidylyltransferase 1B, choline
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Glycogen Granule	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane
	Molecular Function	Catalytic Activity Choline-phosphate Cytidylyltransferase Activity Protein Binding Calmodulin Binding Lipid Binding Transferase Activity Nucleotidyltransferase Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Molecular Function Inhibitor Activity	Catalytic Activity Choline-phosphate Cytidylyltransferase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Phosphatidylcholine Binding Identical Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Phospholipid Biosynthetic Process B Cell Proliferation Isotype Switching Phosphatidylcholine Metabolic Process Organophosphate Biosynthetic Process	Ovarian Follicle Development Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Spermatogenesis Phospholipid Biosynthetic Process Phosphatidylcholine Metabolic Process Organophosphate Biosynthetic Process
Pathways		Synthesis of PC	Synthesis of PC
Drugs		Choline Choline salicylate	Choline Choline salicylate
Diseases
GWAS		Mean platelet volume ( 32888494)
Interacting Genes		16 interacting genes: ACTB AGTRAP CASP6 CASP8 FKBP7 GYS1 MAGEA3 MOB1A MOB3C PCYT1B RBM11 RNF8 SCAMP1 SDCBP SNAPIN TNFRSF10D	7 interacting genes: ACTA1 ACTA2 APP ECPAS PAXIP1 PCYT1A TMEM43
Entrez ID		5130	9468
HPRD ID		00438	05376
Ensembl ID		ENSG00000161217	ENSG00000102230
Uniprot IDs		B4E322 P49585	Q9Y5K3
PDB IDs
Enriched GO Terms of Interacting Partners?			Cell Body Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of Cell Activation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Filopodium Positive Regulation Of Gene Expression Stress Fiber Juxtaglomerular Apparatus Development Positive Regulation Of Hepatic Stellate Cell Migration Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Choline-phosphate Cytidylyltransferase Activity Chorion Development Glomerular Mesangial Cell Development Mesangial Cell Development Positive Regulation Of Hepatic Stellate Cell Activation Smooth Muscle Contractile Fiber Regulation Of Cell Activation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Endoplasmic Reticulum Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Lamellipodium Skeletal Muscle Thin Filament Assembly Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?