PCYT1A and TNFRSF10D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PCYT1A	TNFRSF10D
Description		phosphate cytidylyltransferase 1A, choline	TNF receptor superfamily member 10d
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Glycogen Granule	Plasma Membrane Cell Surface Membrane
	Molecular Function	Catalytic Activity Choline-phosphate Cytidylyltransferase Activity Protein Binding Calmodulin Binding Lipid Binding Transferase Activity Nucleotidyltransferase Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Molecular Function Inhibitor Activity	Transmembrane Signaling Receptor Activity Protein Binding TRAIL Binding
	Biological Process	Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Phospholipid Biosynthetic Process B Cell Proliferation Isotype Switching Phosphatidylcholine Metabolic Process Organophosphate Biosynthetic Process	Apoptotic Process Signal Transduction Negative Regulation Of Apoptotic Process
Pathways		Synthesis of PC	Cell surface interactions at the vascular wall TP53 Regulates Transcription of Death Receptors and Ligands TRAIL signaling
Drugs		Choline Choline salicylate
Diseases
GWAS		Mean platelet volume ( 32888494)	Attention deficit hyperactivity disorder ( 20732625) Lymphocyte percentage of white cells ( 32888494)
Interacting Genes		16 interacting genes: ACTB AGTRAP CASP6 CASP8 FKBP7 GYS1 MAGEA3 MOB1A MOB3C PCYT1B RBM11 RNF8 SCAMP1 SDCBP SNAPIN TNFRSF10D	28 interacting genes: APOL3 ARFIP1 CIAO2A ECPAS FAM114A1 GAD2 HSBP1L1 INPP5K LAT MIEF1 MTERF4 PCYT1A PITPNC1 PLPP6 POLL RBP1 RMDN2 SEMA4G SENP2 SLC39A7 SUCLA2 TARS2 TBRG4 THAP4 TNFRSF10A TNFRSF10B TNFSF10 TUFM
Entrez ID		5130	8793
HPRD ID		00438	04682
Ensembl ID		ENSG00000161217	ENSG00000173530
Uniprot IDs		B4E322 P49585	Q9UBN6
PDB IDs
Enriched GO Terms of Interacting Partners?			TRAIL Binding TRAIL-activated Apoptotic Signaling Pathway Death Receptor Activity Lipid Phosphatase Activity Succinate Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Mitochondrial RNA Metabolic Process Activation Of NF-kappaB-inducing Kinase Activity
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