CYP2C18

Description		cytochrome P450 family 2 subfamily C member 18
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Metal Ion Binding Linoleic Acid Epoxygenase Activity
	Biological Process	Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Linoleic Acid Metabolic Process
Pathways		Xenobiotics
Drugs		N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Clopidogrel active metabolite levels ( 28207573) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to clopidogrel therapy ( 19706858 28207573) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 23093944) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose ( 23755828) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Novel Interacting Genes		1 novel interacting genes: KMT2E
Interacting Genes		5 interacting genes: A2M APOE ECSIT PSEN1 SDC2
Entrez ID		1562
HPRD ID		03085
Ensembl ID		ENSG00000108242
Uniprot IDs		P33260
PDB IDs		2CIK 2H6P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Amyloid Precursor Protein Metabolic Process Enzyme Binding Regulation Of Immune Response Regulation Of Innate Immune Response Extracellular Matrix Negative Regulation Of Phospholipid Efflux Maintenance Of Location Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Response To Amyloid-beta Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Maintenance Of Location In Cell Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Development Regulation Of Neuron Projection Development Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of Core Promoter Binding PDZ Domain Binding Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Set3 Complex Rpd3L-Expanded Complex Blood Microparticle Memory Negative Regulation Of Neuron Projection Development Myeloid Leukocyte Activation Interleukin-8 Binding Regulation Of Immune System Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Postsynapse Organization Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cell Projection Organization Blood Vessel Development Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Phospholipid Efflux
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