CYP2C18

Gene Name		cytochrome P450, family 2, subfamily C, polypeptide 18
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Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity
	Biological Process	Xenobiotic Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Xenobiotics Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations
Drugs
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Response to clopidogrel therapy ( 19706858) Warfarin maintenance dose ( 23755828)
Protein-protein Interactions		5 interactors: A2M APOE ECSIT PSEN1 SDC2
Entrez ID		1562
HPRD ID		03085
Ensembl ID		ENSG00000108242
Uniprot IDs		P33260 Q7Z348
PDB IDs		2H6P
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Neuron Projection Development Response To Stress Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Phototransduction, Visible Light Regulation Of Oxidoreductase Activity Retinoid Metabolic Process Regulation Of Neuron Differentiation Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Extracellular Matrix Disassembly Regulation Of Dendrite Development Detection Of Light Stimulus Cajal-Retzius Cell Differentiation Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Beta-amyloid Formation Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Regulation Of Proteolysis Negative Regulation Of Neuron Projection Development Response To Wounding Regulation Of Neurogenesis Isoprenoid Metabolic Process Negative Regulation Of Cell Projection Organization Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Neurofibrillary Tangle Assembly Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Regulation Of Axonogenesis Regulation Of Cell Development Regulation Of Synaptic Plasticity Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Neuron Apoptotic Process Detection Of Abiotic Stimulus Signal Transduction Positive Regulation Of Phospholipid Efflux
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