CRIM1 and CACNA1A

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		CRIM1	CACNA1A
Description		cysteine rich transmembrane BMP regulator 1	calcium voltage-gated channel subunit alpha1 A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Enzyme Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Insulin-like Growth Factor Receptor Activity PDZ Domain Binding	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Nervous System Development Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Insulin-like Growth Factor Receptor Signaling Pathway	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways			Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs			Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine
GWAS		Adult body size ( 32376654) Anthropometric traits ( 19260139) Bone mineral density (total hip) ( 29883787) Central corneal thickness ( 32528159) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Height ( 25282103 25429064 33713608 31562340) Hip circumference adjusted for BMI ( 34021172) IgE levels in asthmatics ( 23967269) Mean reticulocyte volume ( 32888494) Morning person ( 30696823) QRS duration ( 30012220 27577874) Waist circumference adjusted for body mass index ( 34021172)	Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		4 interacting genes: ATXN7 CACNA1A DYRK1A MTDH	92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		51232	773
HPRD ID		08392	03004
Ensembl ID		ENSG00000150938	ENSG00000141837
Uniprot IDs		Q9NZV1	A0A087WW63 B5TYJ1 O00555 Q9NS89
PDB IDs			3BXK 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Or Depolymerization Histone H3T45 Kinase Activity Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of RNA Splicing Regulation Of Microtubule-based Process Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Intercellular Canaliculus Transcription Coactivator Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Heterochromatin Formation Neurofilament High Voltage-gated Calcium Channel Activity Negative Regulation Of Microtubule Polymerization Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Regulation Of Supramolecular Fiber Organization Calcium Ion Import Across Plasma Membrane Voltage-gated Calcium Channel Complex Calcium Ion Import Into Cytosol Tau-protein Kinase Activity Regulation Of Cellular Response To Stress Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Cytoskeleton Organization Regulation Of Chromatin Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Inclusion Body Assembly Positive Regulation Of RNA Metabolic Process SAGA Complex Transcription Factor TFTC Complex Negative Regulation Of RNA Splicing Protein Serine/threonine/tyrosine Kinase Activity	Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome
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