ENAH and FAT1

Number of citations of the paper that reports this interaction (PMID 15148305)
22

Data Source:
HPRD (in vitro)

		ENAH	FAT1
Gene Name		enabled homolog (Drosophila)	FAT atypical cadherin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Lamellipodium Filopodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding WW Domain Binding	Calcium Ion Binding Protein Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Intracellular Transport T Cell Receptor Signaling Pathway	Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Anatomical Structure Morphogenesis Single Organismal Cell-cell Adhesion Cell Migration
Pathways		TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Obesity ( 21552555)
Protein-Protein Interactions		20 interactors: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP FAT1 FYB GPHN MAPK1 PFN1 PRPF40A ROBO4 SPTA1 TERF2IP TES WAS XIRP1 ZYX	4 interactors: ENAH HOMER1 HOMER3 VASP
Entrez ID		55740	2195
HPRD ID		12360	02986
Ensembl ID		ENSG00000154380	ENSG00000083857
Uniprot IDs		Q8N8S7	Q14517
PDB IDs		2HO2 2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Anatomical Structure Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Development Cell Projection Organization Actin Polymerization Or Depolymerization Neuron Projection Development Locomotion Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Regulation Of Immune System Process Cell Development Axonogenesis Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation T Cell Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cell Motility Neuron Projection Morphogenesis System Development Regulation Of Response To DNA Damage Stimulus Cell Morphogenesis Endocytosis Regulation Of Actin Nucleation	Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Actin Polymerization Or Depolymerization Neural Tube Closure T Cell Receptor Signaling Pathway Neural Tube Formation Antigen Receptor-mediated Signaling Pathway Embryonic Epithelial Tube Formation Epithelial Tube Formation Tube Formation Morphogenesis Of Embryonic Epithelium Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Transport Neural Tube Development Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Tissue Development Epithelial Tube Morphogenesis Axon Guidance Cell Development Tube Morphogenesis Chemical Homeostasis Within A Tissue Immune Response-regulating Signaling Pathway Behavioral Response To Cocaine Signal Transduction Morphogenesis Of An Epithelium Axonogenesis Protein Localization To Synapse Signaling Axon Development Cell Communication Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Regulation Of Calcium Ion Import Skeletal Muscle Fiber Development Regulation Of Ion Transport Positive Regulation Of Immune Response Neuron Projection Morphogenesis Actin Filament-based Process Embryonic Morphogenesis Tissue Morphogenesis Skeletal Muscle Contraction Myotube Cell Development Tube Development Cell Morphogenesis Involved In Differentiation Cellular Response To Stimulus
Tagcloud ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	bcl11b cadherin discovered dnm2 druggable exhibitedthe fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	bcl11b cadherin discovered dnm2 exhibitedthe fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?		druggable