ENAH and TES

Number of citations of the paper that reports this interaction (PMID 12695497)
15

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		ENAH	TES
Gene Name		enabled homolog (Drosophila)	testis derived transcript (3 LIM domains)
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Cell Junction Protein Complex
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding WW Domain Binding	Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Intracellular Transport T Cell Receptor Signaling Pathway	Negative Regulation Of Cell Proliferation
Pathways		TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP FAT1 FYB GPHN MAPK1 PFN1 PRPF40A ROBO4 SPTA1 TERF2IP TES WAS XIRP1 ZYX	12 interactors: ACTL7A ACTN1 ARAP1 ENAH EVL GRIPAP1 SOCS3 SPOCK2 SPTAN1 TLN1 VASP ZYX
Entrez ID		55740	26136
HPRD ID		12360	05833
Ensembl ID		ENSG00000154380	ENSG00000135269
Uniprot IDs		Q8N8S7	A4D0U5 Q9UGI8
PDB IDs		2HO2 2IYB 2XQN	2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Anatomical Structure Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Development Cell Projection Organization Actin Polymerization Or Depolymerization Neuron Projection Development Locomotion Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Regulation Of Immune System Process Cell Development Axonogenesis Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation T Cell Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cell Motility Neuron Projection Morphogenesis System Development Regulation Of Response To DNA Damage Stimulus Cell Morphogenesis Endocytosis Regulation Of Actin Nucleation	Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Actin Polymerization Or Depolymerization Cell Morphogenesis Involved In Differentiation Regulation Of Actin Cytoskeleton Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Regulation Of Cytoskeleton Organization Cell Morphogenesis Regulation Of Actin Filament Polymerization Cellular Component Assembly Neuron Differentiation Cell Junction Assembly Regulation Of Actin Polymerization Or Depolymerization Cell Projection Organization Regulation Of Actin Filament Length Locomotion Organelle Organization Response To Stimulus Nervous System Development Cell-substrate Junction Assembly Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Actin Filament Bundle Assembly Generation Of Neurons Regulation Of Stress Fiber Assembly Regulation Of Protein Complex Assembly Protein Homotetramerization Signal Transduction Platelet Degranulation Actin Filament Reorganization Involved In Cell Cycle Neurogenesis Regulation Of Organelle Organization Signaling Cell Development Response To External Stimulus System Development
Tagcloud ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	apoprotein caenorhabditis canis coat constituent cys displays elegans evasion heptameric homogeneous hyperabundant immunosuppression infective interspersed larvae leader mucin mucins nematode nematodes organized parasitic proline repeats shed sl1 spliced toxocara
Tagcloud (Difference) ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	apoprotein caenorhabditis canis coat constituent cys displays elegans evasion heptameric homogeneous hyperabundant immunosuppression infective interspersed larvae leader mucin mucins nematode nematodes organized parasitic proline repeats shed sl1 spliced toxocara
Tagcloud (Intersection) ?