ZNF219 and GRM3

		ZNF219	GRM3
Description		zinc finger protein 219	glutamate metabotropic receptor 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Plasma Membrane Postsynaptic Density Membrane Axon Presynaptic Membrane Neuron Projection Dendritic Spine Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histamine Receptor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Limb Bud Formation	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Cellular Response To Stress Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways			G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			LY2140023
Diseases
GWAS		Metabolite levels ( 23823483) Resting heart rate ( 27798624)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Hand grip strength (Mahalanobis distance) ( 32235003) LDL cholesterol levels in HIV infection ( 33109212) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 29483656 30285260 28991256 25056061) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		17 interacting genes: AP1M1 ATOSB BCL2L1 CDK4 CSNK2A2 CTBP1 GRIPAP1 LMO1 MAPK3 MAPK8 SH3GL2 SH3KBP1 SUFU TRIM41 TTC32 UBASH3A UFL1	6 interacting genes: CALM1 GRIP1 PICK1 PPM1A SDCBP TAMALIN
Entrez ID		51222	2913
HPRD ID		05435	03070
Ensembl ID		ENSG00000165804	ENSG00000198822
Uniprot IDs		Q9P2Y4	A4D1D0 Q14832
PDB IDs			3SM9 4XAR 5CNK 5CNM 6B7H 7WI6 7WI8 7WIH 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 9II2 9II3
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Glutamatergic Synapse Endocytosis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Immune Response To Tumor Cell Regulation Of T Cell Mediated Immune Response To Tumor Cell MAP Kinase Activity Synapse Regulation Of Protein Localization Response To Lipopolysaccharide Positive Regulation Of Cyclase Activity Stress-activated MAPK Cascade NLRP3 Inflammasome Complex Assembly Negative Regulation Of Signal Transduction Import Into Cell Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cytosol Response To Molecule Of Bacterial Origin Protein Serine Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Response To Tumor Cell Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Catabolic Process Regulation Of Proteolysis Canonical Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of T Cell Mediated Immunity Regulation Of Immune System Process Cellular Response To Lipopolysaccharide Synaptic Vesicle Endocytosis Vesicle-mediated Transport DNA Damage Response Negative Regulation Of Metabolic Process Apoptotic Process In Bone Marrow Cell Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Presynaptic Endocytosis DNA-binding Transcription Factor Binding JUN Phosphorylation UFM1 Ligase Activity Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Extrinsic Component Of Postsynaptic Early Endosome Membrane	Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Regulation Of Endocytosis Regulation Of Transport Monoamine Transport
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