GRM3 and APOA5

Data Source: HiPPIP (Novel)

		GRM3	APOA5
Name		glutamate metabotropic receptor 3	apolipoprotein A5
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Membrane Axon Presynaptic Membrane Neuron Projection Dendritic Spine Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse	Extracellular Region Extracellular Space Endosome Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Vesicle
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Enzyme Binding Phosphatidylcholine Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipase Activator Activity Lipoprotein Lipase Activator Activity Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Cellular Response To Stress Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Modulation Of Chemical Synaptic Transmission	Triglyceride Metabolic Process Lipid Transport Cholesterol Metabolic Process Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Triglyceride Catabolic Process Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Tissue Regeneration Cholesterol Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipid Catabolic Process Acylglycerol Homeostasis Triglyceride Homeostasis
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling
Drugs		LY2140023	None
Diseases		None	Hyperlipoproteinemia, type V
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Asthma ( 27611488 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brachial circumference ( 22479309 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Feeling worry ( 29500382 ) Hand grip strength (Mahalanobis distance) ( 32235003 ) LDL cholesterol levels in HIV infection ( 33109212 ) Neurociticism ( 29500382 ) Neuroticism ( 29255261 ) Refractive error ( 32231278 ) Schizophrenia ( 29483656 30285260 28991256 25056061 ) Seborrheic dermatitis ( 29203360 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 )	Abdominal aortic aneurysm ( 32981348 ) Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 31978080 ) Cardiovascular risk factors (age interaction) ( 20838585 ) Carotenoid and tocopherol levels ( 19185284 ) Cholesterol, total ( 19060911 20686565 26780889 ) Coronary artery disease ( 29212778 29263402 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 21378990 ) Delirium ( 29631748 ) Fasting triglyceride levels ( 32603185 ) HDL cholesterol ( 19060906 20686565 20864672 21347282 26582766 26780889 28371326 29212154 ) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085 ) HDL cholesterol levels ( 26690388 28334899 31694877 ) Hematocrit ( 29403010 ) Hematological and biochemical traits ( 20139978 ) High density lipoprotein cholesterol levels ( 30718733 33339817 ) Hypertriglyceridemia ( 20657596 23505323 27599772 31910446 ) LDL cholesterol ( 18179892 19060911 20686565 20864672 ) LDL cholesterol levels ( 28334899 ) Lipid metabolism phenotypes ( 22286219 ) Lipid traits ( 24023260 24386095 ) Low HDL-cholesterol levels ( 31910446 ) Mean corpuscular hemoglobin concentration ( 29403010 32888494 ) Mean corpuscular volume ( 29403010 ) Mean spheric corpuscular volume ( 32888494 ) Metabolic syndrome ( 21386085 28371326 29212154 30382898 31170924 31910446 ) Metabolically unhealthy in normal weight ( 33500527 ) Metabolically unhealthy in obesity ( 33500527 ) Metabolite levels ( 22916037 23823483 ) Multiple sclerosis ( 31604244 ) NHDL cholesterol to HDL cholesterol ratio ( 28046027 ) Obesity-related traits ( 23251661 ) Phosphatidylinositol levels ( 31551469 ) Phospholipid levels (plasma) ( 22359512 ) Platelet count ( 29403010 ) Postprandial triglyceride levels ( 32603185 ) Response to Vitamin E supplementation ( 22437554 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Total cholesterol levels ( 28334899 29403010 29615537 30275531 ) Triacylglyceride levels ( 31551469 ) Triglyceride levels ( 26763881 28334899 28371326 29212154 29403010 29615537 30718733 32154731 32335043 33339817 ) Triglyceride levels in HIV infection ( 33109212 ) Triglyceride to HDL cholesterol ratio ( 28046027 ) Triglycerides ( 18193043 18193044 19060906 19060911 19074352 20139978 20686565 20864672 21909109 22171074 24097068 26160806 26582766 26780889 29404214 ) Triglycerides-Blood Pressure (TG-BP) ( 21386085 ) Vitamin E levels ( 21729881 ) Waist Circumference - Triglycerides (WC-TG) ( 21386085 )
Interacting Genes		6 interacting genes: CALM1 GRIP1 PICK1 PPM1A SDCBP TAMALIN	16 interacting genes: ACSF2 BMP10 CMTM3 CMTM5 CMTM6 FAS MORN4 MYG1 RAB5B SELENOS SMARCD1 TMEM120B TMEM19 TMEM43 TTPA YIF1A
Entrez ID		2913	116519
HPRD ID		03070	06966
Ensembl ID		ENSG00000198822	ENSG00000110243
Uniprot IDs		A4D1D0 Q14832	A0A0B4RUS7 Q6Q788
PDB IDs		3SM9 4XAR 5CNK 5CNM 6B7H 7WI6 7WI8 7WIH 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 9II2 9II3	Not available
GO Terms Enriched among Interactors		Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Regulation Of Endocytosis Regulation Of Transport Monoamine Transport	None