GRM3 and CDK2AP1

		GRM3	CDK2AP1
Description		glutamate metabotropic receptor 3	cyclin dependent kinase 2 associated protein 1
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GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Membrane Axon Presynaptic Membrane Neuron Projection Dendritic Spine Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol NuRD Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Protein Binding DNA Polymerase Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Cellular Response To Stress Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Modulation Of Chemical Synaptic Transmission	Positive Regulation Of Protein Phosphorylation DNA-templated DNA Replication Regulation Of Transcription By RNA Polymerase II
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		LY2140023
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Hand grip strength (Mahalanobis distance) ( 32235003) LDL cholesterol levels in HIV infection ( 33109212) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 29483656 30285260 28991256 25056061) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Schizophrenia ( 23974872 25056061 29483656) Total cholesterol levels ( 29615537) Tourette syndrome ( 30818990)
Interacting Genes		6 interacting genes: CALM1 GRIP1 PICK1 PPM1A SDCBP TAMALIN	12 interacting genes: ATPAF2 CARD9 CCDC136 CDK2 CDK2AP2 MRFAP1L1 NTAQ1 PICK1 POLA1 SPG21 USP20 ZNF420
Entrez ID		2913	8099
HPRD ID		03070	03726
Ensembl ID		ENSG00000198822	ENSG00000111328
Uniprot IDs		A4D1D0 Q14832	O14519
PDB IDs		3SM9 4XAR 5CNK 5CNM 6B7H 7WI6 7WI8 7WIH 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 9II2 9II3	2KW6
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Regulation Of Endocytosis Regulation Of Transport Monoamine Transport
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