GRM3

Gene Name		glutamate receptor, metabotropic 3
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Presynaptic Membrane Dendritic Spine Postsynaptic Membrane Astrocyte Projection
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity
	Biological Process	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs
Diseases
GWAS		Brachial circumference ( 22479309)
Protein-protein Interactions		6 interactors: CALM1 GRASP GRIP1 PICK1 PPM1A SDCBP
Entrez ID		2913
HPRD ID		03070
Ensembl ID		ENSG00000198822
Uniprot IDs		A4D1D0 B7Z204 F5GYZ2 Q14832
PDB IDs		1S8M 3SM9
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Positive Regulation Of Cellular Metabolic Process Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Transport Protein Localization Membrane Organization Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Neuron Development Negative Regulation Of SMAD Protein Complex Assembly Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Cellular Localization Response To Stimulus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity DNA Methylation Involved In Embryo Development Neuron Differentiation Cell Projection Organization N-terminal Protein Myristoylation Dendritic Spine Maintenance Protein Myristoylation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Calcium Ion Neuronal Ion Channel Clustering Substrate-dependent Cell Migration, Cell Extension Peptidyl-threonine Dephosphorylation Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Phosphoprotein Phosphatase Activity Protein Localization To Membrane Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Regulation Of Actin Nucleation Cell Surface Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi