PCSK1 and PMCH

Number of citations of the paper that reports this interaction (PMID 10037747)
6

Data Source:
HPRD (in vivo)

		PCSK1	PMCH
Gene Name		proprotein convertase subtilisin/kexin type 1	pro-melanin-concentrating hormone
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Apparatus Transport Vesicle Secretory Granule Lumen	Extracellular Region Nucleus
	Molecular Function	Serine-type Endopeptidase Activity	Melanin-concentrating Hormone Activity
	Biological Process	Proteolysis Cell-cell Signaling Metabolic Process Peptide Hormone Processing Peptide Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Insulin Secretion	Neuropeptide Signaling Pathway Synaptic Transmission Multicellular Organismal Development Spermatogenesis Feeding Behavior Cell Differentiation
Pathways		Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Body mass index ( 22344219) Fasting glucose-related traits (interaction with BMI) ( 22581228) Proinsulin levels ( 21873549)	Height ( 19893584)
Protein-Protein Interactions		4 interactors: IAPP PCSK1N PMCH REN	10 interactors: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		5122	5367
HPRD ID		01201	01459
Ensembl ID		ENSG00000175426	ENSG00000183395
Uniprot IDs		P29120	P20382
PDB IDs
Enriched GO Terms of Interacting Partners?		Feeding Behavior Peptide Hormone Processing Behavior Neuropeptide Signaling Pathway Peptide Metabolic Process Hormone Metabolic Process Protein Processing Renin-angiotensin Regulation Of Aldosterone Production Cellular Amide Metabolic Process Regulation Of Hormone Levels Drinking Behavior Response To CGMP Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Negative Regulation Of Bone Resorption Regulation Of Blood Volume By Renin-angiotensin Negative Regulation Of Bone Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Signal Transduction Negative Regulation Of Tissue Remodeling Response To Dietary Excess Signaling Cell Communication Beta-amyloid Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Immobilization Stress Negative Regulation Of Neuroblast Proliferation Eating Behavior Negative Regulation Of Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway Regulation Of Bone Resorption Negative Regulation Of Stem Cell Proliferation Cellular Response To Stimulus Regulation Of Bone Remodeling Cell-cell Signaling Negative Regulation Of Neural Precursor Cell Proliferation Endocrine Pancreas Development Regulation Of Neuroblast Proliferation Cellular Response To Drug Response To Cold Regulation Of Tissue Remodeling G-protein Coupled Receptor Signaling Pathway	Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Nerve Growth Factor Processing Nerve Growth Factor Production Peptide Biosynthetic Process Proteolysis Insulin Processing Insulin Metabolic Process Neuropeptide Signaling Pathway Signal Peptide Processing Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Signaling Cell Communication Cell-cell Signaling Enkephalin Processing Islet Amyloid Polypeptide Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Renin Secretion Into Blood Stream Feeding Behavior Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure G-protein Coupled Receptor Signaling Pathway Secretion By Cell Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Cellular Response To Growth Factor Stimulus Signal Transduction Zygotic Determination Of Anterior/posterior Axis, Embryo Response To Growth Factor G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Secretion Positive Regulation Of Appetite Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Blood Pressure Viral Life Cycle Protein Autoprocessing Adult Feeding Behavior Viral Protein Processing Anterior/posterior Pattern Specification Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		accompanied beneficial beta ccnd2 critical d2 elucidation glut2 granuphilin impaired islets knockout mafa maturation pancreatic pool postnatal prlr prolactin regulates resulted secreting stat5b transactivated transcriptome translocation urocortin vdr znt8
Tagcloud (Difference) ?		accompanied beneficial beta ccnd2 critical d2 elucidation glut2 granuphilin impaired islets knockout mafa maturation pancreatic pool postnatal prlr prolactin regulates resulted secreting stat5b transactivated transcriptome translocation urocortin vdr znt8
Tagcloud (Intersection) ?