PCSK1 and PMCH

Number of citations: 0 (PubMedID 10037747)
Data Source: HPRD (in vivo)

		PCSK1	PMCH
Name		proprotein convertase subtilisin/kexin type 1	pro-melanin concentrating hormone
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Transport Vesicle Secretory Granule Cytoplasmic Vesicle Secretory Granule Lumen Neuron Projection	Extracellular Region Nucleus Synapse
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding	Hormone Activity Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Insulin Processing Peptide Biosynthetic Process	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Feeding Behavior Cell Differentiation Negative Regulation Of Synaptic Transmission, Dopaminergic
Pathways		Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
GWAS		Adult body size ( 32376654 ) Blood protein levels ( 30072576 ) BMI at adiposity peak ( 31840077 ) Body mass index ( 22344219 29273807 28892062 25673413 24861553 ) Body mass index and fasting glucose (pairwise) ( 33619380 ) Fasting blood glucose ( 22581228 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting blood glucose adjusted for BMI ( 25625282 ) Fasting blood proinsulin levels ( 23263489 ) Fasting glucose ( 34059833 ) Glycemic traits (pregnancy) ( 23903356 ) Insulin-related traits (multivariate analysis) ( 32002517 ) Menarche (age at onset) ( 25231870 ) Proinsulin levels ( 21873549 ) Type 2 diabetes ( 32499647 ) Waist circumference ( 23966867 )	Adventurousness ( 30643258 ) Brain morphology (MOSTest) ( 32665545 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Height ( 19893584 ) Number of sexual partners ( 30643258 )
Novel Interactors		1 novel interactors: FER	None recorded
Interacting Genes		4 interacting genes: IAPP PCSK1N PMCH REN	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		5122	5367
HPRD ID		01201	01459
Ensembl ID		ENSG00000175426	ENSG00000183395
Uniprot IDs		P29120	P20382
PDB IDs		Not available	8WSS 8WST 8WWK 8WWL 8WWM 8WWN
GO Terms Enriched among Interactors		Feeding Behavior G Protein-coupled Receptor Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Signaling Receptor Binding Male Gonad Development Adherens Junction Disassembly Hormone Activity Neuropeptide Signaling Pathway Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Signaling Cell Communication Cell-cell Junction Disassembly Negative Regulation Of Synaptic Transmission, Dopaminergic Gonad Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Developmental Process Involved In Reproduction Tyrosine Phosphorylation Of STAT Protein Extracellular Matrix-cell Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kit Signaling Pathway Reproductive Structure Development Amylin Receptor 1 Signaling Pathway Amylin Receptor 3 Signaling Pathway Extracellular Region Amylin Receptor 2 Signaling Pathway Hormone Metabolic Process Juxtaglomerular Apparatus Development Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Protein Processing Renin-angiotensin Regulation Of Aldosterone Production Amylin Receptor Signaling Pathway Regulation Of Blood Volume By Renin-angiotensin Diapedesis Regulation Of Biological Quality Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Mast Cell Activation Response To Macrophage Colony-stimulating Factor Response To CGMP Calcitonin Family Receptor Signaling Pathway Drinking Behavior Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Lipopolysaccharide Protein Maturation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Molecule Of Bacterial Origin Cellular Developmental Process	Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Serine-type Peptidase Activity Protein Maturation Serine-type Endopeptidase Activity Peptidase Activity Endopeptidase Activity Regulation Of Hormone Levels Insulin Processing Peptide Metabolic Process Insulin Metabolic Process Neuropeptide Signaling Pathway Peptide Biosynthetic Process Regulation Of Nerve Growth Factor Production Nerve Growth Factor Production Regulation Of Biological Quality Proteolysis Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Viral Life Cycle Extracellular Space Cytokine Precursor Processing Nerve Growth Factor Binding Hydrolase Activity Endomembrane System Signal Peptide Processing Transport Vesicle Secretory Granule Golgi Lumen Secretion By Cell Peptide Binding Secretion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Trans-Golgi Network Protein Metabolic Process Signaling Cell Communication Extracellular Region Golgi Apparatus Melanin-concentrating Hormone Receptor Activity Short-day Photoperiodism Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Islet Amyloid Polypeptide Processing G Protein-coupled Receptor Signaling Pathway Neuron Projection Cytoplasmic Vesicle