PCSK1 and IAPP

Number of citations of the paper that reports this interaction (PMID 3053705)
24

Data Source:
HPRD (in vivo, in vitro)

		PCSK1	IAPP
Gene Name		proprotein convertase subtilisin/kexin type 1	islet amyloid polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Apparatus Transport Vesicle Secretory Granule Lumen	Extracellular Region Extracellular Space Neuronal Cell Body
	Molecular Function	Serine-type Endopeptidase Activity	Receptor Binding Hormone Activity Identical Protein Binding
	Biological Process	Proteolysis Cell-cell Signaling Metabolic Process Peptide Hormone Processing Peptide Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Insulin Secretion	Apoptotic Process Signal Transduction Cell-cell Signaling Sensory Perception Of Pain Endocrine Pancreas Development Eating Behavior Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption
Pathways		Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR G alpha (s) signalling events GPCR ligand binding Metabolic disorders of biological oxidation enzymes Amyloids GPCR downstream signaling Regulation of beta-cell development Regulation of gene expression in beta cells Calcitonin-like ligand receptors Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Body mass index ( 22344219) Fasting glucose-related traits (interaction with BMI) ( 22581228) Proinsulin levels ( 21873549)
Protein-Protein Interactions		4 interactors: IAPP PCSK1N PMCH REN	6 interactors: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2
Entrez ID		5122	3375
HPRD ID		01201	01005
Ensembl ID		ENSG00000175426	ENSG00000121351
Uniprot IDs		P29120	P10997
PDB IDs			1KUW 2G48 2KB8 2L86 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ
Enriched GO Terms of Interacting Partners?		Feeding Behavior Peptide Hormone Processing Behavior Neuropeptide Signaling Pathway Peptide Metabolic Process Hormone Metabolic Process Protein Processing Renin-angiotensin Regulation Of Aldosterone Production Cellular Amide Metabolic Process Regulation Of Hormone Levels Drinking Behavior Response To CGMP Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Negative Regulation Of Bone Resorption Regulation Of Blood Volume By Renin-angiotensin Negative Regulation Of Bone Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Signal Transduction Negative Regulation Of Tissue Remodeling Response To Dietary Excess Signaling Cell Communication Beta-amyloid Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Immobilization Stress Negative Regulation Of Neuroblast Proliferation Eating Behavior Negative Regulation Of Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway Regulation Of Bone Resorption Negative Regulation Of Stem Cell Proliferation Cellular Response To Stimulus Regulation Of Bone Remodeling Cell-cell Signaling Negative Regulation Of Neural Precursor Cell Proliferation Endocrine Pancreas Development Regulation Of Neuroblast Proliferation Cellular Response To Drug Response To Cold Regulation Of Tissue Remodeling G-protein Coupled Receptor Signaling Pathway	Regulation Of Hormone Levels Peptide Hormone Processing Receptor Internalization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Enkephalin Processing Islet Amyloid Polypeptide Processing Regulation Of CAMP Metabolic Process Organ Senescence Peptide Metabolic Process Protein Localization To Plasma Membrane Detection Of Glucose Basement Membrane Assembly Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Hormone Metabolic Process Response To Chlorate Positive Regulation Of Protein Glycosylation Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Plasma Membrane Organization Response To Iron(II) Ion Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Protein Processing Response To Leucine Cellular Amide Metabolic Process Regulation Of Hormone Secretion Insulin Processing Exocrine Pancreas Development Vascular Smooth Muscle Cell Development Calcium Ion Transport Protein Autoprocessing Regulation Of Protein Glycosylation Positive Regulation Of Vasculogenesis Angiogenesis Insulin Metabolic Process Negative Regulation Of Vascular Permeability Receptor-mediated Endocytosis Transdifferentiation Protein Localization To Membrane Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Protein Transport Regulation Of Vasculogenesis Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Protein Secretion
Tagcloud ?		accompanied beneficial beta ccnd2 critical d2 elucidation glut2 granuphilin impaired islets knockout mafa maturation pancreatic pool postnatal prlr prolactin regulates resulted secreting stat5b transactivated transcriptome translocation urocortin vdr znt8	deficient drives metabolic p53 regression reprogramming tumor upregulation
Tagcloud (Difference) ?		accompanied beneficial beta ccnd2 critical d2 elucidation glut2 granuphilin impaired islets knockout mafa maturation pancreatic pool postnatal prlr prolactin regulates resulted secreting stat5b transactivated transcriptome translocation urocortin vdr znt8	deficient drives metabolic p53 regression reprogramming tumor upregulation
Tagcloud (Intersection) ?