PCSK1 and REN

Number of citations of the paper that reports this interaction (PMID 1597471)
27

Data Source:
HPRD (in vitro, in vivo)

		PCSK1	REN
Gene Name		proprotein convertase subtilisin/kexin type 1	renin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Apparatus Transport Vesicle Secretory Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Activity	Aspartic-type Endopeptidase Activity Receptor Binding Insulin-like Growth Factor Receptor Binding Peptidase Activity
	Biological Process	Proteolysis Cell-cell Signaling Metabolic Process Peptide Hormone Processing Peptide Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Insulin Secretion	Kidney Development Mesonephros Development Angiotensin Maturation Renin-angiotensin Regulation Of Aldosterone Production Proteolysis Regulation Of Blood Pressure Male Gonad Development Hormone-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Drug Response To Immobilization Stress Drinking Behavior Regulation Of MAPK Cascade Cellular Protein Metabolic Process Cell Maturation Beta-amyloid Metabolic Process Response To CAMP Response To CGMP
Pathways		Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs			Remikiren Aliskiren Dimethylformamide 1-Hydroxy-3-Methylbutane 3-Phenyl-1,2-Propandiol 2-Methyl-3-(2-Aminothiazolo)Propanal Enalkiren 2-Cyclopropylmethylenepropanal 1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine N-Methyl-N-(Methylbenzyl)Formamide 1-Hydroxy-2-Amino-3-Cyclohexylpropane N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE 6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE 6-ETHYL-5-[(2S)-1-(3-METHOXYPROPYL)-2-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]PYRIMIDINE-2,4-DIAMINE
Diseases
GWAS		Body mass index ( 22344219) Fasting glucose-related traits (interaction with BMI) ( 22581228) Proinsulin levels ( 21873549)
Protein-Protein Interactions		4 interactors: IAPP PCSK1N PMCH REN	8 interactors: AGT ATP6AP2 CTSB KCTD15 M6PR PCSK1 PCSK5 RENBP
Entrez ID		5122	5972
HPRD ID		01201	01564
Ensembl ID		ENSG00000175426	ENSG00000143839
Uniprot IDs		P29120	P00797
PDB IDs			1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN 2V0Z 2V10 2V11 2V12 2V13 2V16 2X0B 3D91 3G6Z 3G70 3G72 3GW5 3K1W 3KM4 3O9L 3OAD 3OAG 3OOT 3OQF 3OQK 3OWN 3Q3T 3Q4B 3Q5H 3SFC 3VCM 3VSW 3VSX 3VUC 3VYD 3VYE 3VYF 4AMT 4GJ5 4GJ6 4GJ7 4GJ8 4GJ9 4GJA 4GJB 4GJC 4GJD
Enriched GO Terms of Interacting Partners?		Feeding Behavior Peptide Hormone Processing Behavior Neuropeptide Signaling Pathway Peptide Metabolic Process Hormone Metabolic Process Protein Processing Renin-angiotensin Regulation Of Aldosterone Production Cellular Amide Metabolic Process Regulation Of Hormone Levels Drinking Behavior Response To CGMP Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Negative Regulation Of Bone Resorption Regulation Of Blood Volume By Renin-angiotensin Negative Regulation Of Bone Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Signal Transduction Negative Regulation Of Tissue Remodeling Response To Dietary Excess Signaling Cell Communication Beta-amyloid Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Immobilization Stress Negative Regulation Of Neuroblast Proliferation Eating Behavior Negative Regulation Of Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway Regulation Of Bone Resorption Negative Regulation Of Stem Cell Proliferation Cellular Response To Stimulus Regulation Of Bone Remodeling Cell-cell Signaling Negative Regulation Of Neural Precursor Cell Proliferation Endocrine Pancreas Development Regulation Of Neuroblast Proliferation Cellular Response To Drug Response To Cold Regulation Of Tissue Remodeling G-protein Coupled Receptor Signaling Pathway	Peptide Hormone Processing Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Peptide Metabolic Process Regulation Of Blood Pressure Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Blood Circulation Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Peptide Biosynthetic Process Female Pregnancy Uterine Smooth Muscle Contraction Mannose Transport Renin Secretion Into Blood Stream Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Renal System Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity N-acetylmannosamine Metabolic Process Catenin Import Into Nucleus Protein Secretion Cytokine Production Proteolysis Smooth Muscle Cell Proliferation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Angiotensin-mediated Drinking Behavior Regulation Of Renal Output By Angiotensin Nerve Growth Factor Processing Fibroblast Proliferation Astrocyte Activation N-acetylneuraminate Catabolic Process Renin-angiotensin Regulation Of Aldosterone Production Tube Development Regulation Of Blood Vessel Size By Renin-angiotensin Establishment Of Blood-nerve Barrier Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Activation Of JAK2 Kinase Activity Regulation Of NAD(P)H Oxidase Activity Eye Pigmentation Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Activation Of Janus Kinase Activity
Tagcloud ?		accompanied beneficial beta ccnd2 critical d2 elucidation glut2 granuphilin impaired islets knockout mafa maturation pancreatic pool postnatal prlr prolactin regulates resulted secreting stat5b transactivated transcriptome translocation urocortin vdr znt8	4f analogue ant biol brought cap chem eif embo environmentally goss iso le m7g m7gppx m7gtp nucleic pabp poly proximity recycling res ribosome sachs synergistically tail tarun translational whereby
Tagcloud (Difference) ?		accompanied beneficial beta ccnd2 critical d2 elucidation glut2 granuphilin impaired islets knockout mafa maturation pancreatic pool postnatal prlr prolactin regulates resulted secreting stat5b transactivated transcriptome translocation urocortin vdr znt8	4f analogue ant biol brought cap chem eif embo environmentally goss iso le m7g m7gppx m7gtp nucleic pabp poly proximity recycling res ribosome sachs synergistically tail tarun translational whereby
Tagcloud (Intersection) ?