DUSP13B and HOOK2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DUSP13B	HOOK2
Description		dual specificity phosphatase 13B	hook microtubule tethering protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Microtubule HOPS Complex FHF Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Phosphatase Activity	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding
	Biological Process	Protein Dephosphorylation Spermatogenesis Dephosphorylation Negative Regulation Of MAPK Cascade Meiotic Cell Cycle	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Drugs
Diseases
GWAS			High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		14 interacting genes: ACVR1 CALCOCO1 CARD9 CCDC85B HOOK2 HSF2BP INCA1 LMNA PLEKHG4 SH2B2 SMURF1 TGFBR1 TRAF1 ZRANB1	127 interacting genes: ABLIM1 AIRIM AKTIP ANKRD11 ANKRD36BP1 AP1M1 AP2M1 AP4M1 APEX2 ATG5 BYSL CABP2 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13B EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FHIP1B FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEA2 TCEANC TCHP TPM3 TSC1 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844
Entrez ID		51207	29911
HPRD ID		13251	09698
Ensembl ID		ENSG00000079393	ENSG00000095066
Uniprot IDs		A0A9L9PXN7 Q6B8I1 Q9UII6	Q96ED9
PDB IDs		2GWO 2PQ5 5XJV
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Activin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Protein Targeting To Vacuole Involved In Autophagy Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway I-SMAD Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Cell Communication Pharyngeal System Development Regulation Of Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Binding Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Vacuolar Transport Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Ventricular Septum Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Release Of Cytochrome C From Mitochondria Growth Factor Binding Endocardial Cushion Cell Fate Commitment Signal Transduction Cell Surface Receptor Signaling Pathway Perinuclear Endoplasmic Reticulum Lumen Protein Targeting To Vacuole Regulation Of Neuronal Signal Transduction Engulfment Of Target By Autophagosome Cytosol Positive Regulation Of Epithelial To Mesenchymal Transition Establishment Of Protein Localization To Vacuole Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of Neurofibrillary Tangle Assembly	Protein Binding FHF Complex HOPS Complex Protein Localization To Perinuclear Region Of Cytoplasm Centrosome Zinc Ion Binding Cytoskeleton Endosome To Lysosome Transport Spindle Pole Early Endosome To Late Endosome Transport Nucleus Lysosomal Transport Vacuole Organization Clathrin Adaptor Complex Lysosome Organization Microtubule Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vacuolar Transport RNA Splicing
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