DUSP13B and CALCOCO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DUSP13B	CALCOCO1
Description		dual specificity phosphatase 13B	calcium binding and coiled-coil domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromatin Nucleus Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Spermatogenesis Dephosphorylation Negative Regulation Of MAPK Cascade Meiotic Cell Cycle	Signal Transduction Positive Regulation Of Gene Expression Wnt Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS			Panic disorder ( 19165232) Toenail selenium levels ( 25343990) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: ACVR1 CALCOCO1 CARD9 CCDC85B HOOK2 HSF2BP INCA1 LMNA PLEKHG4 SH2B2 SMURF1 TGFBR1 TRAF1 ZRANB1	37 interacting genes: APP APTX ARNT BFSP2 CEP19 CREBBP CRYBA2 CTNNBL1 CWF19L2 CYTH3 DUSP13B ENKD1 EP300 FAM161A FOSL1 FXR1 GABARAPL1 GABARAPL2 GRIK2 IPP ISOC1 KRT15 MAPK1 MYH6 NDC80 NEDD4 PCBD1 POLR2A PRKAA2 RNF8 SH3GL3 SHANK3 SMURF1 SRPK2 TBC1D15 TBC1D17 ZMAT2
Entrez ID		51207	57658
HPRD ID		13251	13868
Ensembl ID		ENSG00000079393	ENSG00000012822
Uniprot IDs		A0A9L9PXN7 Q6B8I1 Q9UII6	Q9P1Z2
PDB IDs		2GWO 2PQ5 5XJV
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Activin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Protein Targeting To Vacuole Involved In Autophagy Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway I-SMAD Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Cell Communication Pharyngeal System Development Regulation Of Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Binding Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Vacuolar Transport Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Ventricular Septum Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Release Of Cytochrome C From Mitochondria Growth Factor Binding Endocardial Cushion Cell Fate Commitment Signal Transduction Cell Surface Receptor Signaling Pathway Perinuclear Endoplasmic Reticulum Lumen Protein Targeting To Vacuole Regulation Of Neuronal Signal Transduction Engulfment Of Target By Autophagosome Cytosol Positive Regulation Of Epithelial To Mesenchymal Transition Establishment Of Protein Localization To Vacuole Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of Neurofibrillary Tangle Assembly	Cytoplasm Regulation Of Long-term Neuronal Synaptic Plasticity Organelle Assembly Regulation Of Glycolytic Process Histone H3K27 Acetyltransferase Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Glycolytic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Cellular Response To Nutrient Levels Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Nucleoplasm Intracellular Signal Transduction Ciliary Basal Body Positive Regulation Of ATP Metabolic Process Regulation Of Synaptic Plasticity Regulation Of Tubulin Deacetylation Regulation Of Long-term Synaptic Potentiation Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Nitrogen Starvation Regulation Of Protein Deacetylation Positive Regulation Of Synaptic Transmission Negative Regulation Of Long-term Synaptic Potentiation N-terminal Protein Amino Acid Acetylation Cellular Response To Stress Peptidyl-lysine Acetylation Intracellular Signaling Cassette Positive Regulation Of Small Molecule Metabolic Process Cytosol Damaged DNA Binding Prp19 Complex Phosphatidylethanolamine Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Heat Ubiquitin Protein Ligase Binding Regulation Of Cell Projection Organization Chromatin Binding Organelle Organization Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Response To Nutrient Levels GABA Receptor Binding Regulation Of Small Molecule Metabolic Process Cellular Response To Starvation
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