CDC42SE1 and OTUD7B

		CDC42SE1	OTUD7B
Description		CDC42 small effector 1	OTU deubiquitinase 7B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Membrane Cell Junction	Nucleus Cytoplasm Cytosol
	Molecular Function	GTPase Inhibitor Activity Protein Binding Small GTPase Binding	DNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding K48-linked Deubiquitinase Activity
	Biological Process	Phagocytosis Signal Transduction Regulation Of Cell Shape Regulation Of Rho Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Immune System Process Mucosal Immune Response Proteolysis Protein Deubiquitination Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination TORC1 Signaling TORC2 Signaling Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases
Drugs
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: CDC42 DAPK1 RAC1 SNCA	19 interacting genes: ATG14 CCNB1 CDC20 CDIP1 DAZAP2 EPM2AIP1 FZR1 HSFY1 HSFY2 OTULIN PIK3C3 PSMB1 SAXO4 SOX2 SPART TRAF6 UBC UBE2S ZDHHC17
Entrez ID		56882	56957
HPRD ID		16694	10313
Ensembl ID		ENSG00000197622	ENSG00000264522
Uniprot IDs		Q9NRR8	Q6GQQ9
PDB IDs			5LRU 5LRV 5LRW
Enriched GO Terms of Interacting Partners?		Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Response To Type II Interferon Regulation Of Hydrogen Peroxide Metabolic Process GTP-dependent Protein Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Phagocytosis, Engulfment Postsynapse Regulation Of Synaptic Vesicle Recycling Cell Projection Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Invagination Regulation Of Synapse Organization Non-canonical Wnt Signaling Pathway Regulation Of Endocytosis Lamellipodium Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Neuronal Synaptic Plasticity Regulation Of Cell Communication GTP Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Signaling Regulation Of Supramolecular Fiber Organization Cellular Response To Type II Interferon Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Microtubule Polymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cytoplasmic Ribonucleoprotein Granule Regulation Of Protein-containing Complex Assembly Positive Regulation Of Intracellular Signal Transduction Endocytosis Regulation Of Stress Fiber Assembly GBD Domain Binding Storage Vacuole Positive Regulation Of Organelle Organization Cell Junction Organization	Positive Regulation Of Ubiquitin Protein Ligase Activity Anaphase-promoting Complex Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Cell Division Positive Regulation Of Post-translational Protein Modification Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Phosphatidylinositol 3-kinase Complex, Class III Ubiquitin-protein Transferase Activator Activity Proteolysis Regulation Of Protein Ubiquitination Ubiquitin Ligase Activator Activity Protein Ubiquitination Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Post-translational Protein Modification Autophagosome Assembly Cytoplasm Autophagosome Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Targeting To Lysosome Positive Regulation Of Catalytic Activity Phagophore Assembly Site Modification-dependent Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Response To DDT Cell Cycle Phase Transition Metaphase/anaphase Transition Of Meiosis I Macroautophagy Extrinsic Component Of Phagophore Assembly Site Membrane Negative Regulation Of Collateral Sprouting In Absence Of Injury Perforant Pathway To Dendrate Granule Cell Synapse Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Vacuole Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Glucose Starvation Autophagosome Maturation
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