OTULINL and TMX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTULINL	TMX2
Description		OTU deubiquitinase with linear linkage specificity like	thioredoxin related transmembrane protein 2
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	Protein Binding Ubiquitin-like Protein Peptidase Activity Ubiquitin Binding	Protein Binding Disulfide Oxidoreductase Activity Identical Protein Binding
	Biological Process	Protein Deubiquitination	Brain Development
Pathways
Drugs
Diseases
GWAS		Asthma ( 32296059 34103634)	Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Problematic alcohol use ( 32451486) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		10 interacting genes: AQP6 GOLT1A HSD17B11 JAGN1 RETREG3 SLC30A8 TMEM14B TMEM31 TMEM86B TMX2	163 interacting genes: AGPAT3 AGPAT4 AGPAT5 AIG1 AQP6 ARV1 ASGR1 ASPH ATXN1 BDKRB1 BET1 BNIP1 BNIP2 BNIP3 BRICD5 BTN2A2 C2CD2L CCDC167 CCL2 CD81 CDIPT CDS2 CMTM7 COL8A2 COMMD8 COX20 CTSA CTXN3 CXCL16 CXorf66 CYBC1 CYP4F2 DERL1 DGAT2L6 EMD EMP3 F2RL1 FA2H FAM177A1 FAM241B FAM3C FAXDC2 FDFT1 FUNDC2 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 HACD2 HHATL HMOX1 HMOX2 HSD17B11 HSD17B13 HTATIP2 IER3 IER3IP1 IGFBP5 INSIG2 ITGAM LEPROT LEPROTL1 LHFPL5 LRAT MALL MFF MGLL MGST3 MIP MLN MS4A1 MTNR1A NAT8 NDUFA3 NINJ2 NRM NSDHL NSG1 ORMDL2 OTULINL PAEP PEDS1-UBE2V1 PEX16 PKMYT1 PLP2 PNLIPRP1 PRAF2 PRB1 PTAFR PTPN9 RABAC1 REEP2 REEP4 RFT1 RNF24 RTP2 RUSF1 SACM1L SCAMP5 SCD SELENOK SERF1A SERF1B SERP2 SFT2D1 SFXN1 SFXN3 SLC22A2 SLC29A2 SLC35A1 SLC67A1 SLC71A2 SMAGP SMCO4 SMIM1 STATH STX12 STX3 STX7 THBD THSD7B TMBIM6 TMEM115 TMEM120A TMEM120B TMEM121 TMEM128 TMEM140 TMEM14B TMEM14C TMEM176A TMEM201 TMEM203 TMEM208 TMEM222 TMEM239 TMEM254 TMEM31 TMEM50B TMEM51 TMEM65 TMEM71 TMEM86B TMEM97 TPRG1 TRAM1L1 TREX1 TSNARE1 TSPAN2 TVP23B UBE2J1 UNC93A VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB WFDC2 YIF1A YIPF1 YIPF2 YIPF6
Entrez ID		54491	51075
HPRD ID		07733	07159
Ensembl ID		ENSG00000145569	ENSG00000213593
Uniprot IDs		Q9NUU6	Q9Y320
PDB IDs		6DRM	2DJ0
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Insulin Metabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Insulin Secretion Peptide Hormone Secretion Endoplasmic Reticulum Organization Peptide Secretion D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Hormone Secretion Carbon Dioxide Transmembrane Transporter Activity Membrane Carbon Dioxide Transmembrane Transport Endoplasmic Reticulum Membrane Steroid Dehydrogenase Activity Androgen Catabolic Process Regulation Of Hormone Levels Protein Localization To Extracellular Region Granulocyte Colony-stimulating Factor Signaling Pathway Response To Monosaccharide Hormone Transport Establishment Of Protein Localization To Extracellular Region Response To Glucose Protein Secretion Amide Transport Peptide Transport Endoplasmic Reticulum-autophagosome Adaptor Activity Zinc:proton Antiporter Activity Monoatomic Anion Channel Activity Ammonium Channel Activity Renal Water Transport Disulfide Oxidoreductase Activity Mitochondrial Membrane Hormone Metabolic Process Estrogen Biosynthetic Process Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Insulin Secretion Response To Carbohydrate Signal Release Neutrophil Differentiation Substrate Localization To Autophagosome Zinc Ion Import Across Plasma Membrane Insulin Processing Ammonium Transmembrane Transport Regulation Of Peptide Hormone Secretion Zinc Ion Import Into Organelle Golgi Cis Cisterna	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex SNAP Receptor Activity Cortical Endoplasmic Reticulum Protein Binding CDP-diacylglycerol Metabolic Process Vesicle-mediated Transport Lipid Biosynthetic Process Membrane Organization Nuclear Envelope Endomembrane System Membrane Docking CDP-diacylglycerol Biosynthetic Process Organelle Fusion Organelle Membrane Fusion Intracellular Transport Lipid Metabolic Process Organelle Localization By Membrane Tethering Golgi Membrane Membrane Fusion Endoplasmic Reticulum Organization Cellular Localization Establishment Of Localization In Cell Sterol Biosynthetic Process Vesicle Fusion Golgi Trans Cisterna Golgi Medial Cisterna Golgi Vesicle Transport Heme Oxidation Heme Oxygenase (decyclizing) Activity Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Nuclear Inner Membrane Response To Oxygen-glucose Deprivation Regulation Of Cellular Localization Amyloid Fibril Formation Mitochondrial Outer Membrane Steroid Biosynthetic Process Monoatomic Ion Transmembrane Transporter Activity SNARE Complex Assembly Glycerolipid Metabolic Process FFAT Motif Binding Steroid Dehydrogenase Activity Serine Import Into Mitochondrion Vesicle Docking Golgi Apparatus Heme Metabolic Process Spindle Pole Centrosome Cholesterol Biosynthetic Process
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