EGFL7 and NOTCH2

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, two hybrid)

		EGFL7	NOTCH2
Name		EGF like domain multiple 7	notch receptor 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Surface Extracellular Matrix	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding	Transcription Coactivator Activity Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Cell Differentiation Negative Regulation Of Notch Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Liver Development Placenta Development Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Atrioventricular Node Development Pulmonary Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Humoral Immune Response Notch Signaling Pathway Determination Of Left/right Symmetry Nervous System Development Axon Guidance Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Hemopoiesis Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Septum Morphogenesis Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Tumor Cell Proximal Tubule Development Podocyte Development Glomerular Capillary Formation Hepatocyte Proliferation Liver Morphogenesis Positive Regulation Of MiRNA Transcription Regulation Of Hemopoiesis Cholangiocyte Proliferation Regulation Of Osteoclast Development
Pathways		None	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription
Diseases		None	Alagille syndrome Hajdu-Cheney syndrome Type II diabetes mellitus
GWAS		Diastolic blood pressure ( 30224653 ) Lean body mass ( 28552196 ) Mean reticulocyte volume ( 32888494 ) Metabolite levels ( 23823483 ) Triiodothyronine levels and thyroxine levels ( 30843173 )	Blood protein levels ( 30072576 ) Hepatocyte growth factor levels ( 25998175 ) Nevus count or cutaneous melanoma ( 32341527 ) Systemic lupus erythematosus ( 28714469 ) Type 1 diabetes ( 34012112 34127860 ) Type 2 diabetes ( 18372903 30054458 30297969 )
Interacting Genes		18 interacting genes: FXR1 FXR2 GFI1B GNE HEXIM2 HGS HOXA1 HSD3B7 MID2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NUFIP2 RASSF10 SMARCD1 SPAG8 UBC	31 interacting genes: ANKRD28 CCR2 CNTN1 CRKL CST6 DLL1 DTX1 DTX3 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SHANK3 SMAD1
Entrez ID		51162	4853
HPRD ID		16351	02606
Ensembl ID		ENSG00000172889	ENSG00000134250
Uniprot IDs		Q9UHF1	Q04721 Q6IQ50
PDB IDs		Not available	2OO4 5MWB
GO Terms Enriched among Interactors		Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Differentiation Cellular Response To Tumor Cell Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Development Notch Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Transcription Coactivator Activity Luteolysis Tube Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Development Regulation Of Smooth Muscle Cell Differentiation Atrioventricular Node Development Positive Regulation Of Cell Differentiation Glomerular Capillary Formation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Metabolic Process Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Long-term Neuronal Synaptic Plasticity Artery Morphogenesis Regulation Of Developmental Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Neurogenesis Regulation Of Gene Expression Left/right Axis Specification Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Blood Vessel Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Nervous System Development Pulmonary Valve Morphogenesis Signaling Receptor Activity Translation Regulator Activity Positive Regulation Of Transcription By RNA Polymerase II Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Positive Regulation Of Developmental Process	Notch Signaling Pathway Regulation Of Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Notch Binding Mononuclear Cell Differentiation Regulation Of Cell Adhesion Lymphocyte Differentiation Leukocyte Differentiation Marginal Zone B Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Timing Of Cell Differentiation Positive Regulation Of Signaling Lymphocyte Activation Somitogenesis Regulation Of Development, Heterochronic Signal Transduction Segmentation O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Positive Regulation Of Signal Transduction Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Leukocyte Activation Cell Differentiation Pattern Specification Process MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transcription Coactivator Activity Immune System Process Endothelial Cell Fate Specification Compartment Pattern Specification Mature B Cell Differentiation Involved In Immune Response Cell Activation Myoblast Differentiation Regulation Of Cell Population Proliferation Mature B Cell Differentiation Loop Of Henle Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Animal Organ Morphogenesis