EGFL7 and HSD3B7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EGFL7	HSD3B7
Description		EGF like domain multiple 7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Surface Extracellular Matrix	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding	3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Cell Differentiation Negative Regulation Of Notch Signaling Pathway	Lipid Metabolic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process B Cell Chemotaxis
Pathways			Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs
Diseases			Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4) Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Diastolic blood pressure ( 30224653) Lean body mass ( 28552196) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		18 interacting genes: FXR1 FXR2 GFI1B GNE HEXIM2 HGS HOXA1 HSD3B7 MID2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NUFIP2 RASSF10 SMARCD1 SPAG8 UBC	56 interacting genes: ADAMTSL4 AGR2 ANAPC11 APPBP2 ARID5A ASB12 BTN2A2 C22orf39 COMT CREB5 CYSRT1 DAPP1 EFEMP1 EFEMP2 EGFL7 ELOVL4 EMG1 FBLN2 GLRX3 HOXA1 HSD17B13 ICAM1 KPNA4 KPRP KRT31 KRT40 KRT86 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-2 KRTAP4-2 KRTAP5-9 LCE4A LINGO1 MEI4 MEOX2 MGAT5B NOTCH2NLA NR4A3 OTX2 PYGL RBP3 REEP4 RGS17 SPRY2 SSC4D TMEM31 TRIM42 YPEL3 ZBTB42 ZNF655
Entrez ID		51162	80270
HPRD ID		16351	09680
Ensembl ID		ENSG00000172889	ENSG00000099377
Uniprot IDs		Q9UHF1	Q9H2F3
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Differentiation Cellular Response To Tumor Cell Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Development Notch Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Transcription Coactivator Activity Luteolysis Tube Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Development Regulation Of Smooth Muscle Cell Differentiation Atrioventricular Node Development Positive Regulation Of Cell Differentiation Glomerular Capillary Formation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Metabolic Process Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Long-term Neuronal Synaptic Plasticity Artery Morphogenesis Regulation Of Developmental Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Neurogenesis Regulation Of Gene Expression Left/right Axis Specification Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Blood Vessel Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Nervous System Development Pulmonary Valve Morphogenesis Signaling Receptor Activity Translation Regulator Activity Positive Regulation Of Transcription By RNA Polymerase II Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Positive Regulation Of Developmental Process	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Epidermis Development Dopamine Secretion Epidermal Growth Factor Receptor Binding
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