EGFL7 and GFI1B

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EGFL7	GFI1B
Gene Name		EGF-like-domain, multiple 7	growth factor independent 1B transcription repressor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Nucleus Transcription Factor Complex Nuclear Matrix
	Molecular Function	Notch Binding Calcium Ion Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Notch Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Chromatin Modification Hemopoiesis Regulation Of Histone H3-K4 Methylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: GFI1B NOTCH1 NOTCH2 NOTCH3 NOTCH4 SMARCD1	71 interactors: ACTN1 AES AGPAT6 AGRN AJUBA ANKS3 ATXN2 BECN1 BEGAIN BEND5 BRCA1 BRE CCDC136 CCDC85B CENPB CENPJ COPS5 DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 PSMA3 RAB11FIP4 RCHY1 RINT1 RNF31 RUNDC3A TAF1 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRD1 ZNRF3
Entrez ID		51162	8328
HPRD ID		16351	05088
Ensembl ID		ENSG00000172889	ENSG00000165702
Uniprot IDs		Q9UHF1	Q5VTD9
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cell Fate Commitment Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Interleukin-4 Production Blood Vessel Development Vasculature Development Regulation Of Endothelial Cell Differentiation Glomerulus Vasculature Development Negative Regulation Of Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Cardiovascular System Development Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis System Development Heart Valve Development Positive Regulation Of BMP Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Angiogenesis RNA Biosynthetic Process Multicellular Organismal Development Cell Fate Determination Regulation Of Gene Expression Anatomical Structure Development Cardiac Septum Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Glomerulus Development Morphogenesis Of An Epithelial Sheet Blood Vessel Morphogenesis Pattern Specification Process Endothelial Cell Differentiation Developmental Process Neuron Fate Commitment Cardiac Septum Development Organ Development Regulation Of BMP Signaling Pathway Morphogenesis Of An Epithelium Endothelium Development	Regulation Of Cellular Process Cell Communication Regulation Of Cellular Component Organization Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Signaling Cellular Response To Stimulus Signal Transduction Response To Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Growth Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Canonical Wnt Signaling Pathway Developmental Process Secretion Negative Regulation Of Signaling Regulation Of Locomotion Cellular Process Regulation Of Cellular Component Movement Focal Adhesion Assembly Protein Localization Protein Ubiquitination Cellular Localization Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Cell-substrate Adhesion Adherens Junction Assembly Cell Differentiation Cellular Component Assembly Neurogenesis Auditory Receptor Cell Fate Commitment Anatomical Structure Development Regulation Of Gene Expression Regulation Of Proteolysis Regulation Of Apoptotic Process Cell-substrate Junction Assembly Regulation Of I-kappaB Kinase/NF-kappaB Signaling Secretion By Cell Regulation Of Cell Proliferation Receptor Clustering Regulation Of Vesicle-mediated Transport
Tagcloud ?		coculture consistently controlling crosstalk differentiation dissect embryonic endocrine endothelial endothelium epithelium handle hesc impair maintain mechanistic organogenesis pancreatic paradigm pp precise progenitor progenitors renewal signals stepwise toward transgenic unclear	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Difference) ?		coculture consistently controlling crosstalk differentiation dissect embryonic endocrine endothelial endothelium epithelium handle hesc impair maintain mechanistic organogenesis pancreatic paradigm pp precise progenitor progenitors renewal signals stepwise toward transgenic unclear	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Intersection) ?