ING4 and MSX1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ING4	MSX1
Gene Name		inhibitor of growth family, member 4	msh homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Methylated Histone Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding
	Biological Process	DNA Replication Chromatin Organization Protein Acetylation Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Growth	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Muscle Organ Development Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Pituitary Gland Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of BMP Signaling Pathway Midbrain Development Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Nail Plate Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Negative Regulation Of Striated Muscle Cell Differentiation Palate Development Face Morphogenesis Bone Morphogenesis Cartilage Morphogenesis Mammary Gland Epithelium Development BMP Signaling Pathway Involved In Heart Development Cellular Response To Nicotine Activation Of Meiosis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS			Congenital heart disease ( 23708191) Electrocardiographic conduction measures ( 19389651)
Protein-Protein Interactions		17 interactors: CDC34 EGLN1 EP300 HIST1H3A HIST3H3 HNRNPD HOXB9 JADE1 JADE2 KAT7 MSX1 MYC NAV2 RELA SUV39H1 TLX3 TP53	24 interactors: AES CREBBP DLX2 DLX5 HOXC8 ING4 LHX2 MED19 MSX2 NMNAT1 PAX3 PAX9 PIAS1 POU2F1 RGS7 SP1 SUMO1 SUMO2 TAF1 TBP TLE1 TLE2 TLE4 TP53
Entrez ID		51147	4487
HPRD ID		09774	00866
Ensembl ID		ENSG00000111653	ENSG00000163132
Uniprot IDs		Q9UNL4	P28360
PDB IDs		2K1J 2M1R 2PNX 2VNF 4AFL
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Histone H4-K12 Acetylation Histone H4 Acetylation Heterocycle Metabolic Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Hypoxia Transcription, DNA-templated Cellular Response To Decreased Oxygen Levels Peptidyl-lysine Modification Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Cellular Response To Oxygen Levels Histone Acetylation Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Cellular Nitrogen Compound Metabolic Process Protein Acetylation Chromatin Modification Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Histone H3 Acetylation Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Response To Nicotine Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Positive Regulation Of Gene Expression Organ Morphogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Morphogenesis Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Notch Signaling Pathway Pattern Specification Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Embryo Development Organ Development Regulation Of Cellular Process Protein Sumoylation Negative Regulation Of Binding Regulation Of Signal Transduction
Tagcloud ?		aad adenovirus adopted apparently arrested bax bcl blot caspase cleaved cne differential efect g2 measure mtt nasopharyngeal obviously overexpressed p21 pe probable regulating rgd rt survivin synergies vector western	anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx2 ofc ofcs orofacial palate postulated satb2 ski tceb3
Tagcloud (Difference) ?		aad adenovirus adopted apparently arrested bax bcl blot caspase cleaved cne differential efect g2 measure mtt nasopharyngeal obviously overexpressed p21 pe probable regulating rgd rt survivin synergies vector western	anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx2 ofc ofcs orofacial palate postulated satb2 ski tceb3
Tagcloud (Intersection) ?