ING4 and NOLC1

Number of citations: 68 (PubMedID 31754246)
Data Source: BioGRID (affinity chromatography technology, pull down)

		ING4	NOLC1
Name		inhibitor of growth family member 4	nucleolar and coiled-body phosphoprotein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytosol Intermediate Filament Cytoskeleton	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Histone H3K4me3 Reader Activity	Nucleotide Binding RNA Binding Protein Binding ATP Binding GTP Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity Molecular Function Inhibitor Activity
	Biological Process	Regulation Of Cell Growth Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Acetylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Growth Regulation Of Cell Cycle DNA Replication-dependent Chromatin Disassembly Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Biosynthetic Process	Mitotic Cell Cycle RRNA Processing Regulation Of Translation Nucleolus Organization Neural Crest Formation Neural Crest Cell Development
Pathways		HATs acetylate histones	None
Drugs		None	Doxorubicin
GWAS		No GWAS studies recorded	Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Smoking initiation ( 33082346 ) Triglyceride levels ( 32203549 )
Interacting Genes		23 interacting genes: BEX3 CDC34 EGLN1 EP300 GNL3 GRIPAP1 H3-4 H3C1 HNRNPD HOXB9 JADE2 KAT7 MAPK8IP2 MSX1 MYC NAV2 NOLC1 RELA SUV39H1 TLX3 TP53 TRIM55 TRIM63	19 interacting genes: APP CEBPA CEBPB COIL CSNK2A1 CSNK2B E2F4 ERG GTF2B ING4 KBTBD8 MDM2 OGT POLR1A PRKACA SRPK2 USP4 YWHAG YWHAQ
Entrez ID		51147	9221
HPRD ID		09774	03864
Ensembl ID		ENSG00000111653	ENSG00000166197
Uniprot IDs		Q9UNL4	B2RAU8 Q14978 Q96J17
PDB IDs		2K1J 2M1R 2PNX 2VNF 4AFL	Not available
GO Terms Enriched among Interactors		Nucleoplasm Nucleus Regulation Of Cellular Response To Stress Chromatin Organization Positive Regulation Of MiRNA Transcription Chromatin Remodeling Epigenetic Regulation Of Gene Expression Positive Regulation Of MiRNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of MiRNA Transcription Histone Acetyltransferase Complex Regulation Of DNA Biosynthetic Process Regulation Of MiRNA Metabolic Process Chromatin Negative Regulation Of Catabolic Process Response To Actinomycin D Regulation Of Telomere Maintenance Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Chromosome Nucleic Acid Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Response To Hypoxia Transcription Initiation-coupled Chromatin Remodeling Circadian Rhythm Chromatin Binding Transcription Coactivator Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Nicotine Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Histone H4K16 Acetyltransferase Activity Positive Regulation Of Gene Expression, Epigenetic Response To UV Response To Decreased Oxygen Levels RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Oxygen Levels Canonical NF-kappaB Signal Transduction Anterior/posterior Pattern Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Protein Domain Specific Binding Nucleus Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Chromatin Binding TORC1 Signaling Intracellular Signal Transduction C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process TOR Signaling Regulation Of Primary Metabolic Process CHOP-C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Assembly Regulation Of TORC1 Signaling Regulation Of Translation Regulation Of Translational Initiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Cellular Response To Nutrient Levels Negative Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Protein-containing Complex Organization Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Response To Nutrient Levels RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Component Assembly Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Translational Initiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of TOR Signaling Regulation Of Glycolytic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression