ING4 and PTPN22

Data Source: HiPPIP (Novel)

		ING4	PTPN22
Name		inhibitor of growth family member 4	protein tyrosine phosphatase non-receptor type 22
Structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytosol Intermediate Filament Cytoskeleton	Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Histone H3K4me3 Reader Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Cell Growth Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Acetylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Growth Regulation Of Cell Cycle DNA Replication-dependent Chromatin Disassembly Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Biosynthetic Process	Immune System Process Lipid Metabolic Process Autophagy Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphoanandamide Dephosphorylation Negative Regulation Of JUN Kinase Activity Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of P38MAPK Cascade
Pathways		HATs acetylate histones	Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse
Diseases		None	Type I diabetes mellitus
GWAS		No GWAS studies recorded	Alopecia areata ( 25608926 ) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 ) Arthritis (juvenile idiopathic) ( 33106285 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229 ) Autoimmune traits (pleiotropy) ( 30572963 ) Breast cancer ( 23535729 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 18587394 21102463 28067908 23128233 ) Giant cell arteritis ( 25817017 ) Granulocyte count ( 27863252 ) Graves' disease ( 22922229 ) Gut microbiota (bacterial taxa) ( 27694959 ) Hashimoto thyroiditis ( 22922229 ) Hodgkin's lymphoma ( 30194254 ) Hypothyroidism ( 22493691 27182965 ) Idiopathic inflammatory myopathy ( 26362759 ) IgM levels ( 28628107 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Late-onset myasthenia gravis ( 26562150 ) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083 ) Lymphocyte count ( 27863252 32888494 ) Medication use (drugs used in diabetes) ( 31015401 ) Medication use (thyroid preparations) ( 31015401 ) Myasthenia gravis ( 23055271 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 ) Obesity-related traits ( 23251661 ) Pediatric autoimmune diseases ( 26301688 ) Polymyositis ( 26362759 ) Rheumatoid arthritis ( 30423114 30572963 30891314 17554300 17804836 18794853 19503088 21156761 24449572 24390342 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Severe autoimmune type 2 diabetes ( 34737425 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systemic lupus erythematosus ( 28714469 19838195 26502338 27399966 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Thyroid peroxidase antibody levels ( 24586183 ) Type 1 diabetes ( 21829393 17554260 17554300 17632545 25751624 19430480 30572963 18978792 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926 ) Vitiligo ( 27723757 20410501 ) White blood cell count ( 32888494 27863252 )
Novel Interactors		1 novel interactors: PTPN22	6 novel interactors: GSTP1 HMGCS2 ING4 NOTCH2 SARS1 WARS2
Interacting Genes		23 interacting genes: BEX3 CDC34 EGLN1 EP300 GNL3 GRIPAP1 H3-4 H3C1 HNRNPD HOXB9 JADE2 KAT7 MAPK8IP2 MSX1 MYC NAV2 NOLC1 RELA SUV39H1 TLX3 TP53 TRIM55 TRIM63	13 interacting genes: CBL CD247 CD3E CLK1 CRK CSK EGFR GRB2 LCK PRKCD SRPK2 VAV1 ZAP70
Entrez ID		51147	26191
HPRD ID		09774	06100
Ensembl ID		ENSG00000111653	ENSG00000134242
Uniprot IDs		Q9UNL4	B4DZW8 F5H2S8 G3K0T4 Q9Y2R2
PDB IDs		2K1J 2M1R 2PNX 2VNF 4AFL	2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51 7AAM
GO Terms Enriched among Interactors		Nucleoplasm Nucleus Regulation Of Cellular Response To Stress Chromatin Organization Positive Regulation Of MiRNA Transcription Chromatin Remodeling Epigenetic Regulation Of Gene Expression Positive Regulation Of MiRNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of MiRNA Transcription Histone Acetyltransferase Complex Regulation Of DNA Biosynthetic Process Regulation Of MiRNA Metabolic Process Chromatin Negative Regulation Of Catabolic Process Response To Actinomycin D Regulation Of Telomere Maintenance Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Chromosome Nucleic Acid Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Response To Hypoxia Transcription Initiation-coupled Chromatin Remodeling Circadian Rhythm Chromatin Binding Transcription Coactivator Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Nicotine Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Histone H4K16 Acetyltransferase Activity Positive Regulation Of Gene Expression, Epigenetic Response To UV Response To Decreased Oxygen Levels RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Oxygen Levels Canonical NF-kappaB Signal Transduction Anterior/posterior Pattern Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade T Cell Costimulation Cell-cell Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Immune System Process Leukocyte Activation Protein Tyrosine Kinase Binding T Cell Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of T Cell Activation Fc Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Positive Regulation Of Cell Adhesion T Cell Activation Protein Kinase Activity Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion T Cell Receptor Complex Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Gamma-delta T Cell Activation Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Positive Regulation Of Signal Transduction Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Protein Phosphatase Binding Regulation Of Cell Activation Gamma-delta T Cell Receptor Complex Ephrin Receptor Binding