ING4 and NAV2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		ING4	NAV2
Name		inhibitor of growth family member 4	neuron navigator 2
Structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytosol Intermediate Filament Cytoskeleton	Interstitial Matrix Nucleus Nucleoplasm Extracellular Matrix
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Histone H3K4me3 Reader Activity	Nucleotide Binding Helicase Activity Protein Binding ATP Binding Heparin Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity
	Biological Process	Regulation Of Cell Growth Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Acetylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Growth Regulation Of Cell Cycle DNA Replication-dependent Chromatin Disassembly Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Biosynthetic Process	Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Nervous System Development Sensory Perception Of Sound Sensory Perception Of Smell Locomotory Behavior Optic Nerve Development Glossopharyngeal Nerve Development Vagus Nerve Development Cerebellar Cortex Development Neurogenesis
Pathways		HATs acetylate histones	None
GWAS		No GWAS studies recorded	Adverse response to drug ( 30420678 ) Atrial fibrillation ( 29892015 30061737 ) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery aneurysm in Kawasaki disease ( 27171184 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) General cognitive ability ( 29844566 ) Hepatitis ( 25705159 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Lateral thalamic nuclei volume ( 34006833 ) Low susceptibility to hepatitis C infection ( 31206233 ) Macular thickness ( 30535121 ) Monobrow ( 27182965 ) Obesity-related traits ( 23251661 ) PR interval ( 32439900 30046033 ) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762 ) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306 ) Waist circumference ( 28552196 )
Interacting Genes		23 interacting genes: BEX3 CDC34 EGLN1 EP300 GNL3 GRIPAP1 H3-4 H3C1 HNRNPD HOXB9 JADE2 KAT7 MAPK8IP2 MSX1 MYC NAV2 NOLC1 RELA SUV39H1 TLX3 TP53 TRIM55 TRIM63	12 interacting genes: ADAT2 APC CFAP58 ING4 ING5 MORF4L1 PIAS2 PRPF3 PSTPIP1 RBM15 RBM15B RRAS
Entrez ID		51147	89797
HPRD ID		09774	07385
Ensembl ID		ENSG00000111653	ENSG00000166833
Uniprot IDs		Q9UNL4	A7E2D6 Q8IVL1
PDB IDs		2K1J 2M1R 2PNX 2VNF 4AFL	2YRN
GO Terms Enriched among Interactors		Nucleoplasm Nucleus Regulation Of Cellular Response To Stress Chromatin Organization Positive Regulation Of MiRNA Transcription Chromatin Remodeling Epigenetic Regulation Of Gene Expression Positive Regulation Of MiRNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of MiRNA Transcription Histone Acetyltransferase Complex Regulation Of DNA Biosynthetic Process Regulation Of MiRNA Metabolic Process Chromatin Negative Regulation Of Catabolic Process Response To Actinomycin D Regulation Of Telomere Maintenance Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Chromosome Nucleic Acid Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Response To Hypoxia Transcription Initiation-coupled Chromatin Remodeling Circadian Rhythm Chromatin Binding Transcription Coactivator Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Nicotine Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Histone H4K16 Acetyltransferase Activity Positive Regulation Of Gene Expression, Epigenetic Response To UV Response To Decreased Oxygen Levels RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Oxygen Levels Canonical NF-kappaB Signal Transduction Anterior/posterior Pattern Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	DNA Replication-dependent Chromatin Disassembly Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Histone H3K4me3 Reader Activity Histone Acetyltransferase Complex Chromatin Organization RNA Modification Nucleoplasm Protein Acetylation Fibroblast Proliferation TRNA Wobble Adenosine To Inosine Editing TRNA-specific Adenosine-34 Deaminase Activity Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process RNA Methylation Regulation Of DNA Biosynthetic Process RNA Metabolic Process