KLF11 and NFYC

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KLF11	NFYC
Name		KLF transcription factor 11	nuclear transcription factor Y subunit gamma
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion Nuclear Body	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Endothelin Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		None	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Diseases		Maturity onset diabetes of the young (MODY)	None
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690 ) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690 ) Feeling worry ( 29500382 ) Heel bone mineral density ( 30598549 ) Height ( 28552196 ) Mean spheric corpuscular volume ( 32888494 ) Neurociticism ( 29500382 ) Prostate cancer ( 23535732 )	Adult body size ( 32376654 ) Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926 ) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926 ) Depressive and manic episodes in bipolar disorder ( 26297903 ) Platelet count ( 21507922 ) Refractive error ( 32231278 )
Novel Interactors		None recorded	2 novel interactors: JAK1 JUN
Interacting Genes		13 interacting genes: APH1A APPBP2 ATXN1 CBX1 CBX3 CLU HDAC1 MAPK1 NFYC SIN3A TIMM13 TXNDC9 YWHAZ	65 interacting genes: ADGRF5 ADNP2 APOL4 ARID2 ATF6 ATF6B BDH2 BICRA BICRAL CEP76 CIART CIC CRX CSN2 CXorf38 DR1 DST ELF1 FAM168A GAPDH HGS HSFY1 HSFY2 KLF11 KLF15 KLHDC7B LIN54 LMO4 MYC NFYA NFYB NUTM2F OSTF1 PAX4 PAX5 PAX6 POGZ POU3F2 POU6F1 POU6F2 PRR20B PRR20C PRR20D PRR20E RAD52 SAE1 SMAD2 SMAD3 SMAP1 SNX2 SP1 SP2 SP4 SREBF2 STOX1 TAF11 TAF12 TAF6 TBP UBXN7 USF3 ZDHHC17 ZMYM6 ZNF34 ZSCAN1
Entrez ID		8462	4802
HPRD ID		04488	05633
Ensembl ID		ENSG00000172059	ENSG00000066136
Uniprot IDs		B7ZAX4 O14901 Q53QU8	Q13952
PDB IDs		Not available	1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS 7AH8 8QU2 8QU3 8QU4
GO Terms Enriched among Interactors		Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation Heterochromatin Chromatin Binding Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Methyltransferase Binding Sin3-type Complex Regulation Of RNA Metabolic Process Enzyme Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of RNA Biosynthetic Process Pericentric Heterochromatin Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Targeting Perinuclear Endoplasmic Reticulum Lumen Nucleus Regulation Of Neuronal Signal Transduction Protein Sequestering Activity Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Nucleoplasm Histone Deacetylase Complex Spindle Negative Regulation Of Protein Localization To Nucleus Site Of DNA Damage Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Chromatin ERK1 And ERK2 Cascade Rhythmic Process Positive Regulation Of Gliogenesis Transcription Repressor Complex Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Positive Regulation Of Neurofibrillary Tangle Assembly Krueppel-associated Box Domain Binding Cytosine Metabolic Process Synaptic Target Recognition Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Metabolic Process Protein-containing Complex Regulation Of Gene Expression Central Nervous System Myelin Maintenance	Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Protein-DNA Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Sequence-specific DNA Binding Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription R-SMAD Binding Transcription Preinitiation Complex Assembly Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Transcription Factor TFIID Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Co-SMAD Binding Regulation Of MiRNA Metabolic Process