SLC39A9 and CERS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC39A9	CERS3
Description		solute carrier family 39 member 9	ceramide synthase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Zinc Ion Transmembrane Transporter Activity Androgen Binding Protein Binding Zinc Efflux Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Metal Ion Transport Transmembrane Transport Bicellular Tight Junction Assembly Zinc Ion Transmembrane Transport Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Cellular Response To Testosterone Stimulus	Lipid Metabolic Process Sphingolipid Metabolic Process Epidermis Development Sphingolipid Biosynthetic Process Keratinocyte Differentiation Ceramide Biosynthetic Process Cornification
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Childhood body mass index ( 31752434) Cotinine glucuronidation ( 25293881)
Interacting Genes		40 interacting genes: ANKRD46 APH1A AQP6 BNIP2 CBARP CD79A CERS3 CPLX4 CRB3 CREB3L1 CREB3L3 CYB5B ELOVL5 EVI2B FCER1G FFAR2 GJA8 GPR101 HERPUD2 HTR2C LNPEP MANBAL MGST3 NEU1 RTP2 SERINC2 SLC10A6 SLC16A2 SLC39A2 SLC61A1 SLC66A1 SLC71A2 SLC7A1 SSMEM1 TM4SF18 TMEM140 TMEM237 TMEM86B TRHR VMP1	5 interacting genes: NEU1 ORMDL3 PCBD2 SLC29A2 SLC39A9
Entrez ID		55334	204219
HPRD ID		15387	13961
Ensembl ID		ENSG00000029364	ENSG00000154227
Uniprot IDs		B4DDK0 C4N9M8 M0QX28 Q9NUM3	Q8IU89
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Lysine Transport Plasma Membrane Positive Regulation Of Acute Inflammatory Response L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport L-lysine Transmembrane Transport Regulation Of Acute Inflammatory Response Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Aromatic Amino Acid Transport L-arginine Transmembrane Transport Azole Transmembrane Transport Endoplasmic Reticulum Membrane Basic Amino Acid Transmembrane Transport Protein Binding Transmembrane Transport Amino Acid Transmembrane Transport Basic Amino Acid Transport Response To Unfolded Protein Phospholipid Scramblase Activity Plasma Membrane Phospholipid Scrambling	Cytidine Transmembrane Transporter Activity Uracil Transmembrane Transport Thymine Transport Uridine Transmembrane Transport Inosine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Cytidine Transport Uracil Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transport Guanine Transmembrane Transporter Activity Pyrimidine Nucleoside Transport Guanine Transport Guanine Transmembrane Transport Adenosine Transport Hypoxanthine Transport Nucleoside Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Membrane Lipid Metabolic Process Alpha-sialidase Activity Sphingolipid Metabolic Process Ceramide Metabolic Process Exo-alpha-sialidase Activity Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Androgen Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Negative Regulation Of Ceramide Biosynthetic Process Intracellular Sphingolipid Homeostasis Nucleoside Transmembrane Transport Adenine Transport Nucleoside Transport Pyrimidine Nucleobase Transport Negative Regulation Of Sphingolipid Biosynthetic Process Purine Nucleobase Transmembrane Transport Tetrahydrobiopterin Biosynthetic Process Serine Palmitoyltransferase Complex Ganglioside Catabolic Process Tetrahydrobiopterin Metabolic Process Purine Nucleobase Transport Nucleobase Transport Sphingomyelin Biosynthetic Process Pyrimidine-containing Compound Transmembrane Transport Pteridine-containing Compound Biosynthetic Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Ceramide Biosynthetic Process Xenobiotic Transmembrane Transport Oligosaccharide Catabolic Process
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