GPATCH8 and RNPS1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		GPATCH8	RNPS1
Description		G-patch domain containing 8	RNA binding protein with serine rich domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Hemopoiesis	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome DNA-templated Transcription MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Pulse pressure ( 30578418)
Interacting Genes		6 interacting genes: APH1A ATXN1 ATXN1L NUMBL RNPS1 SUMO2	55 interacting genes: ABI2 CCNL1 CHERP CLK2 CLK3 DVL2 ELOA2 FAM81B GOLGA6L9 GPATCH8 HEXIM2 HOXD4 LUC7L3 NKTR OGT PICK1 PIN1 PNN PRPF38A PSTPIP1 RBMY1F RBMY1J SAP18 SART3 SDCBP2 SRP54 SRRM4 SRSF1 SRSF11 SRSF3 SRSF6 SRSF7 SRSF9 STX11 TBC1D26 TRA2A TRA2B TRIM41 U2AF1 UBQLN4 UPF2 USP4 YTHDC1 YWHAB YWHAG ZBTB14 ZNF165 ZNF286A ZNF345 ZNF394 ZNF41 ZNF473 ZNF490 ZNF660 ZSCAN30
Entrez ID		23131	10921
HPRD ID		11089	07341
Ensembl ID		ENSG00000186566	ENSG00000205937
Uniprot IDs		Q9UKJ3	D3DU92 H3BMS0 Q15287
PDB IDs			4A8X
Enriched GO Terms of Interacting Partners?		POZ Domain Binding Social Behavior Lung Alveolus Development DNA-templated Transcription Macromolecule Metabolic Process RNA Binding Memory Neuroblast Division In Subventricular Zone Learning ASAP Complex Poly(G) Binding Positive Regulation Of Neurogenesis Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Postsynapse Brain Development Notch Receptor Processing Gamma-secretase Complex Positive Regulation Of Hematopoietic Stem Cell Proliferation Learning Or Memory Positive Regulation Of Nervous System Development Amyloid-beta Formation Nuclear Inclusion Body Transcription By RNA Polymerase II Lateral Ventricle Development Membrane Protein Intracellular Domain Proteolysis Cognition Protein Tag Activity Amyloid Precursor Protein Catabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Neurogenesis Endopeptidase Activator Activity	MRNA Processing RNA Splicing Regulation Of RNA Splicing Nuclear Speck MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleus Regulation Of MRNA Processing RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Binding Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process MRNA Splice Site Recognition Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Positive Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Exon-exon Junction Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Identical Protein Binding Protein Domain Specific Binding Negative Regulation Of MRNA Metabolic Process Pre-mRNA Binding MRNA Transport ASAP Complex RNA Transport Phosphoserine Residue Binding RS Domain Binding Protein Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Nucleobase-containing Compound Transport Cajal Body
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