GPATCH8 and APH1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GPATCH8	APH1A
Description		G-patch domain containing 8	aph-1A gamma-secretase subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Golgi Cisterna Membrane Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	MRNA Splicing, Via Spliceosome Hemopoiesis	Metanephros Development Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process
Pathways			Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs			E-2012 MK-0752
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Pulse pressure ( 30578418)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26835600 26955885) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: APH1A ATXN1 ATXN1L NUMBL RNPS1 SUMO2	36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1
Entrez ID		23131	51107
HPRD ID		11089	06360
Ensembl ID		ENSG00000186566	ENSG00000117362
Uniprot IDs		Q9UKJ3	B4DUG7 Q96BI3
PDB IDs			5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8X52 8X53 8X54
Enriched GO Terms of Interacting Partners?		POZ Domain Binding Social Behavior Lung Alveolus Development DNA-templated Transcription Macromolecule Metabolic Process RNA Binding Memory Neuroblast Division In Subventricular Zone Learning ASAP Complex Poly(G) Binding Positive Regulation Of Neurogenesis Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Postsynapse Brain Development Notch Receptor Processing Gamma-secretase Complex Positive Regulation Of Hematopoietic Stem Cell Proliferation Learning Or Memory Positive Regulation Of Nervous System Development Amyloid-beta Formation Nuclear Inclusion Body Transcription By RNA Polymerase II Lateral Ventricle Development Membrane Protein Intracellular Domain Proteolysis Cognition Protein Tag Activity Amyloid Precursor Protein Catabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Neurogenesis Endopeptidase Activator Activity	Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Amyloid Precursor Protein Metabolic Process Presynaptic Membrane Membrane Protein Proteolysis Notch Signaling Pathway Cajal-Retzius Cell Differentiation Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Cell Surface Receptor Signaling Pathway Growth Factor Receptor Binding Regulation Of Transport Adenohypophysis Development Positive Regulation Of Growth Hormone Secretion Membrane CAMP Response Element Binding Protein Binding Regulation Of Protein Metabolic Process Negative Regulation Of Transport Homeostatic Process Regulation Of Growth Hormone Secretion Membrane Protein Intracellular Domain Proteolysis Golgi Membrane Synaptic Membrane Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Signal Transduction Vesicle Targeting Epithelial Cell Proliferation Protein Processing Endopeptidase Activator Activity Regulation Of Primary Metabolic Process Regulation Of Synaptic Plasticity G Protein-coupled Dopamine Receptor Signaling Pathway Cerebral Cortex Neuron Differentiation
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