ABHD5 and PNPLA2

Number of citations of the paper that reports this interaction (PMID 17189257)
70

Data Source:
BioGRID (fluorescent resonance energy transfer, protein complementation assay)

		ABHD5	PNPLA2
Gene Name		abhydrolase domain containing 5	patatin-like phospholipase domain containing 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lipid Particle Cytosol Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Membrane Lipid Particle Cytosol Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Lipase Activity Lysophosphatidic Acid Acyltransferase Activity	Triglyceride Lipase Activity
	Biological Process	Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Cell Differentiation Small Molecule Metabolic Process Positive Regulation Of Lipoprotein Lipase Activity	Phospholipid Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Particle Organization Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways		Metabolism of lipids and lipoproteins Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Lipid digestion, mobilization, and transport	Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PLIN1 PLIN2 PNPLA2	10 interactors: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		51099	57104
HPRD ID		11986	11443
Ensembl ID			ENSG00000177666
Uniprot IDs		Q8WTS1	Q96AD5
PDB IDs
Enriched GO Terms of Interacting Partners?		Triglyceride Catabolic Process Acylglycerol Catabolic Process Lipid Storage Triglyceride Metabolic Process Neutral Lipid Metabolic Process Cellular Lipid Metabolic Process Cellular Lipid Catabolic Process Lipid Metabolic Process Lipid Catabolic Process Lipid Localization Acylglycerol Acyl-chain Remodeling Glycerolipid Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Small Molecule Metabolic Process Positive Regulation Of Triglyceride Catabolic Process Lipid Particle Organization Negative Regulation Of Lipid Storage Positive Regulation Of Lipid Catabolic Process Regulation Of Triglyceride Metabolic Process Long-chain Fatty Acid Transport Regulation Of Lipid Catabolic Process Regulation Of Lipid Storage Fatty Acid Transport Catabolic Process Monocarboxylic Acid Transport	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Post-Golgi Vesicle-mediated Transport Cellular Response To Cobalt Ion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Triglyceride Catabolic Process Regulation Of GTPase Activity Mullerian Duct Regression Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Receptor Recycling Response To Cobalt Ion Golgi Vesicle Transport Short-term Memory COPI-coated Vesicle Budding Positive Regulation Of Lipoprotein Lipase Activity COPI Coating Of Golgi Vesicle Positive Regulation Of Metabolic Process
Tagcloud ?		adenomatous aerobic ampkalpha apc attributable cgi comparative correlates crc crcs deficiency enhances falls glycolysis hydrolase intestine knockout link lipolysis lipolytic malignancies malignant mesenchymal polyps robustly shift substantially suppressing transformation	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?		adenomatous aerobic ampkalpha apc attributable comparative correlates crc crcs deficiency enhances falls glycolysis hydrolase intestine knockout link lipolysis lipolytic malignancies malignant mesenchymal polyps robustly shift substantially suppressing transformation	agpat2 anomaly atgl ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?		abhd5 cgi