ABHD5 and PLIN1

Number of citations of the paper that reports this interaction (PubMedID 15136565)
0

Data Source:
HPRD (in vitro, two hybrid)

		ABHD5	PLIN1
Description		abhydrolase domain containing 5, lysophosphatidic acid acyltransferase	perilipin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lipid Droplet Cytosol	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Triacylglycerol Lipase Activity Protein Binding Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity Lipase Activator Activity	Protein Binding Lipid Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipid Catabolic Process Lipid Homeostasis	Lipid Metabolic Process Lipid Catabolic Process Cellular Response To Cold
Pathways		Triglyceride catabolism	Triglyceride catabolism Transcriptional regulation of white adipocyte differentiation NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases		Dorfman-Chanarin syndrome; Chanarin-Dorfman syndrome
GWAS		A body shape index ( 34021172) General risk tolerance (MTAG) ( 30643258) Inflammatory skin disease ( 25574825) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	HDL cholesterol ( 30275531)
Interacting Genes		21 interacting genes: CERCAM COQ8A DGAT2L6 GAD2 GET1 GRIA4 MIEF1 PCNX2 PLIN1 PLIN2 PLIN3 PNPLA2 RBFA RNF24 RUSC1 SH3GLB1 SLC44A3 TMEM14B TMEM31 TPD52L2 ZCCHC12	4 interacting genes: ABHD5 BSCL2 LIPE PRKACA
Entrez ID		51099	5346
HPRD ID		11986	01364
Ensembl ID		ENSG00000011198	ENSG00000166819
Uniprot IDs		A0A0S2Z5D6 A0A2U3TZT9 C9J1D1 Q8WTS1	O60240
PDB IDs
Enriched GO Terms of Interacting Partners?		Lipid Droplet Disassembly Lipid Droplet Positive Regulation Of Triglyceride Storage Acylglycerol Acyl-chain Remodeling Lipid Storage Lipid Droplet Organization Regulation Of Lipid Storage Cellular Response To Glucose Starvation Organelle Disassembly Positive Regulation Of Lipid Storage Glycerolipid Metabolic Process ADP Binding Protein Localization To Vacuolar Membrane Cellular Response To Starvation Response To Starvation Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity	Lipid Droplet Triacylglycerol Lipase Activity Regulation Of Lipid Metabolic Process Regulation Of Lipid Catabolic Process Lipid Metabolic Process Sterol Ester Esterase Activity Diacylglycerol Lipase Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Triglyceride Storage Lipase Activator Activity Retinyl-palmitate Esterase Activity Lipid Catabolic Process Diacylglycerol Catabolic Process CAMP-dependent Protein Kinase Activity Monoacylglycerol Lipase Activity Phosphate-containing Compound Metabolic Process Glycerolipid Metabolic Process Protein Phosphorylation CAMP-dependent Protein Kinase Complex Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus High-density Lipoprotein Particle Assembly Mitochondrial Protein Catabolic Process CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Channel Activator Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Lysophosphatidic Acid Acyltransferase Activity Positive Regulation Of Triglyceride Catabolic Process Interleukin-2-mediated Signaling Pathway Cellular Response To Epinephrine Stimulus Negative Regulation Of Catabolic Process Phosphorylation Lipase Activity Ether Lipid Metabolic Process Diacylglycerol Metabolic Process Triglyceride Catabolic Process Acylglycerol Catabolic Process Catabolic Process Regulation Of Hormone Levels Protein-lipid Complex Assembly Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Cardiac Conduction Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Interleukin-2 Production
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