ABHD5 and PCNX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABHD5	PCNX2
Description		abhydrolase domain containing 5, lysophosphatidic acid acyltransferase	pecanex 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lipid Droplet Cytosol	Cellular_component Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Triacylglycerol Lipase Activity Protein Binding Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity Lipase Activator Activity	Molecular_function Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipid Catabolic Process Lipid Homeostasis	Biological_process
Pathways		Triglyceride catabolism
Drugs
Diseases		Dorfman-Chanarin syndrome; Chanarin-Dorfman syndrome
GWAS		A body shape index ( 34021172) General risk tolerance (MTAG) ( 30643258) Inflammatory skin disease ( 25574825) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: CERCAM COQ8A DGAT2L6 GAD2 GET1 GRIA4 MIEF1 PCNX2 PLIN1 PLIN2 PLIN3 PNPLA2 RBFA RNF24 RUSC1 SH3GLB1 SLC44A3 TMEM14B TMEM31 TPD52L2 ZCCHC12	3 interacting genes: ABHD5 ORMDL1 SLC30A2
Entrez ID		51099	80003
HPRD ID		11986	15108
Ensembl ID		ENSG00000011198	ENSG00000135749
Uniprot IDs		A0A0S2Z5D6 A0A2U3TZT9 C9J1D1 Q8WTS1	A6NKB5 B3KNZ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Lipid Droplet Disassembly Lipid Droplet Positive Regulation Of Triglyceride Storage Acylglycerol Acyl-chain Remodeling Lipid Storage Lipid Droplet Organization Regulation Of Lipid Storage Cellular Response To Glucose Starvation Organelle Disassembly Positive Regulation Of Lipid Storage Glycerolipid Metabolic Process ADP Binding Protein Localization To Vacuolar Membrane Cellular Response To Starvation Response To Starvation Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity	Zinc Ion Import Into Zymogen Granule Chemical Homeostasis Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Homeostatic Process Zinc Export Across Plasma Membrane Phospholipid Biosynthetic Process Lipid Homeostasis Negative Regulation Of Triglyceride Storage Lipase Activator Activity Zinc:proton Antiporter Activity Zinc Ion Import Into Lysosome Regulation Of Lipid Metabolic Process Phospholipid Metabolic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Serine Palmitoyltransferase Complex Vacuolar Transmembrane Transport Positive Regulation Of Triglyceride Catabolic Process Secretory Vesicle Zinc Ion Import Into Organelle Lysophosphatidic Acid Acyltransferase Activity Sphingomyelin Biosynthetic Process Zymogen Granule Membrane Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transporter Activity 1-acylglycerol-3-phosphate O-acyltransferase Activity Lipid Biosynthetic Process Organophosphate Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Triacylglycerol Lipase Activity Sphingomyelin Metabolic Process Regulation Of Membrane Lipid Metabolic Process Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Cellular Homeostasis Zinc Ion Transmembrane Transporter Activity Zinc Ion Transport Zinc Ion Transmembrane Transport Positive Regulation Of Lipid Catabolic Process Phosphatidic Acid Biosynthetic Process Motor Behavior Intracellular Zinc Ion Homeostasis Phosphatidic Acid Metabolic Process Carboxylic Ester Hydrolase Activity Regulation Of Triglyceride Metabolic Process Response To Zinc Ion Regulation Of Lipid Storage
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